Comorbidities and Age Are Associated With Persistent COVID-19 PCR Positivity.
Comorbidities and Age Are Associated With Persistent COVID-19 PCR Positivity.
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DOI：
10.3389/fcimb.2021.650753
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发表时间：
2021
影响因子：
5.7
通讯作者：
El Khoury J
中科院分区：
文献类型：
--
作者：
Aldhaeefi M;Tahir Z;Cote DJ;Izzy S;El Khoury J
人口统计和合并症对 COVID-19 鼻咽拭子 PCR 阳性持续时间的影响尚不清楚。我们分析的目的是确定年龄、重症监护病房 (ICU) 入院、合并症和种族对大型医院住院患者的 COVID-19 PCR 阳性持续时间的影响。我们研究了来自大型医院系统的 530 名患者，主要终点是住院期间或出院后的任何时间 SARS-CoV-2 病毒 RNA PCR 呈阴性的时间。我们纳入了在 2020 年 2 月 1 日至 2020 年 4 月 14 日期间住院、门诊或急诊室就诊时检测出 COVID-19 呈阳性的 18 岁或以上患者。总体而言，我们的患者群体中有 315 名 (59.4%) 在初次检测呈阳性后 4 周，SARS-CoV-2 病毒 RNA PCR 检测结果仍然呈阳性。我们发现，年龄>70岁、慢性肾病、高血压、高脂血症、肥胖或冠状动脉疾病与初次诊断后4周以上持续PCR阳性有关。在解释新冠肺炎 PCR 检测呈阳性时，应考虑年龄和合并症的存在。
The impact of demographics and comorbidities on the duration of COVID-19 nasopharyngeal swab PCR positivity remains unclear. The objective of our analysis is to determine the impact of age, intensive care unit (ICU) admission, comorbidities, and ethnicity on the duration of COVID-19 PCR positivity among hospitalized patients in a large group of hospital. We studied 530 patients from a large hospital system and time to SARS-CoV-2 virus RNA PCR negativity at any-time during hospitalization or following discharge from the hospital was the primary endpoint. We included patients 18 years or older who tested positive for COVID-19 during an inpatient, outpatient, or emergency room visit between February 1, 2020, and April 14, 2020. Overall, 315 (59.4%) of our patient population continued to have a positive SARS-CoV-2 virus RNA PCR 4 weeks after the initial positive test. We found that age>70 years, chronic kidney disease, hypertension, hyperlipidemia, obesity, or coronary artery disease are associated with persistent PCR positivity for more than 4 weeks after initial diagnosis. Age, and the presence of co-morbidities should be taken into consideration when interpreting a positive COVID PCR test.