Identification of biomarkers for the detection of early stage lung adenocarcinoma by microarray profiling of long noncoding RNAs
Identification of biomarkers for the detection of early stage lung adenocarcinoma by microarray profiling of long noncoding RNAs
复制标题
通过长非编码 RNA 的微阵列分析鉴定用于检测早期肺腺癌的生物标志物
DOI：
10.1016/j.lungcan.2015.02.009
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发表时间：
2015-05-01
期刊：
影响因子：
5.3
通讯作者：
Mao, Hongju
中科院分区：
文献类型：
--
作者：
Wang, Ping;Lu, Shaohua;Mao, Hongju
背景资料：肺腺癌是全球所有癌症中预后最差的一种，部分原因是缺乏可靠的早期检测手段。长链非编码RNA（lncRNA）在某些类型的肿瘤中表达失调，然而lncRNA在肺腺癌中的作用尚不清楚。方法：采用基因芯片技术，研究了人早期肺腺癌及相应癌旁非肿瘤组织（NT）中lncRNA的表达。从微阵列分析中，与NT相比，在三种早期肺腺癌组织中总共有1170个IncRNA显著差异表达（倍数变化>= 2.0，p
Background: Lung adenocarcinoma has one of the poorest outcomes of any cancer worldwide, in part due to the lack of a reliable means of early detection. Long noncoding RNAs (IncRNAs) have been shown to be deregulated in some types of cancer; however, the contributions of lncRNAs to lung adenocarcinoma remain unknown.Methods: We described the expression profile of IncRNAs in human lung adenocarcinoma at an early stage and the corresponding adjacent nontumorous tissues (NT) by microarray. From the microarray analysis, a total of 1170 IncRNAs were significantly differentially expressed in three early stage lung adenocarcinoma tissues compared with NT (fold-change >= 2.0, p