Glucagon-like peptide 1 induces natriuresis in healthy subjects and in insulin-resistant obese men
Glucagon-like peptide 1 induces natriuresis in healthy subjects and in insulin-resistant obese men
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DOI：
10.1210/jc.2003-031403
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发表时间：
2004-06-01
影响因子：
5.8
通讯作者：
Beglinger, C
中科院分区：
文献类型：
--
作者：
Gutzwiller, JP;Tschopp, S;Beglinger, C
胰高血糖素样肽-1-（7-36）-酰胺（GLP-1）参与饱腹感控制和葡萄糖稳态。动物研究表明GLP-1在水和盐的体内平衡中的生理作用。本研究的目的是确定GLP-1对健康和肥胖男性的水和钠排泄的影响。在一项双盲、安慰剂对照、交叉研究中检查了30名受试者（平均体重指数，36 kg/m2），以证明3小时输注GLP-1对尿钠排泄、尿量在健康受试者中，输注GLP-1引起尿钠排泄的剂量依赖性增加（从74 +/- 8至143 +/- 18 mmol/180 min，P = 0.0013）。在肥胖男性中，（从59至96 mmol/180 min，P = 0.015），尿H（+）分泌减少（从1.1到0.3 pmol/180 min，P = 0.013），肾小球滤过率下降6%（从151 +/-8至142 +/-8 ml/min，P = 0.022）。在肥胖男性中，GLP-1的静脉内输注增强钠排泄，减少H（+）分泌，并减少肾小球超滤。这些结果表明，在近端肾小管的行动和潜在的肾脏保护作用。
Glucagon-like peptide-1-(7-36)-amide (GLP-1) is involved in satiety control and glucose homeostasis. Animal studies suggest a physiological role for GLP-1 in water and salt homeostasis. This study's aim was to define the effects of GLP-1 on water and sodium excretion in both healthy and obese men.Fifteen healthy subjects and 16 obese men ( mean body mass index, 36 kg/m(2)) were examined in a double-blind, placebo-controlled, crossover study to demonstrate the effects of a 3-h infusion of GLP-1 on urinary sodium excretion, urinary output, and the glomerular filtration rate after an iv 9.9-g salt load.Infusion of GLP-1 evoked a dose-dependent increase in urinary sodium excretion in healthy subjects ( from 74 +/- 8 to 143 +/- 18 mmol/180 min, P = 0.0013). In obese men, there was a significant increase in urinary sodium excretion ( from 59 to 96 mmol/180 min, P = 0.015), a decrease in urinary H(+) secretion ( from 1.1 to 0.3 pmol/180 min, P = 0.013), and a 6% decrease in the glomerular filtration rate ( from 151 +/- 8 to 142 +/- 8 ml/min, P = 0.022).Intravenous infusions of GLP-1 enhance sodium excretion, reduce H(+) secretion, and reduce glomerular hyperfiltration in obese men. These findings suggest an action at the proximal renal tubule and a potential renoprotective effect.