Black and White adults' perspectives on the genetics of nicotine addiction susceptibility.
Black and White adults' perspectives on the genetics of nicotine addiction susceptibility.
复制标题
黑人和白人成年人对尼古丁成瘾易感性遗传学的看法。
DOI：
10.1016/j.addbeh.2011.02.007
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发表时间：
2011
影响因子：
4.4
通讯作者：
Shields,AlexandraE
中科院分区：
文献类型：
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作者：
Park,ElyseR;Kleimann,Susan;Youatt,EmilyJ;Lockhart,Abigail;Campbell,EricG;Levy,DouglasE;Halbert,ChanitaHughes;Schmieder,Erin;Krishna,Rasika;Shields,AlexandraE
AIMS 新兴研究可能很快就会通过基因定制的戒烟治疗提高戒烟率。本研究的目的是探讨在此背景下个人对基因检测的信念和态度，以及这些信念和态度在不同种族群体中有何不同。设计两个站点定性研究。方法2007 年，在阿拉巴马州蒙哥马利和马里兰州巴尔的摩，对 51 名黑人和 55 名白人成年参与者进行了 11 个焦点小组调查。测量询问了有关吸烟成瘾、遗传在尼古丁中的作用等问题。 成瘾易感性，并接受基因检测以接受量身定制的戒烟治疗。使用内容分析对数据进行分析。发现大多数参与者认为吸烟是一种成瘾，但不愿意认可遗传学在尼古丁成瘾易感性中发挥作用的观点。然而，91% 的白人参与者和 62% 的黑人参与者表示，他们可能会进行基因测试，以便与最佳戒烟治疗相匹配。主要的潜在好处是一种模糊的感觉，即关于自己的更多知识是有价值的。主要障碍包括对测试不感兴趣和怀疑、不愿意相信基因在尼古丁成瘾或治疗反应中发挥作用，以及担心心理后果。结论大多数参与者，特别是黑人参与者，不相信基因在尼古丁成瘾易感性中发挥重要作用，但愿意接受基因测试。参与者发现根据基因型调整吸烟治疗有一些好处。然而，参与者也对这项测试表示怀疑，并担心其后果；这些问题需要在临床中得到解决。
AIMSEmerging research may soon lead to improved quit rates via genetically-tailored smoking cessation treatment. The purpose of this study was to explore individuals' beliefs and attitudes about genetic testing in this context, and how these may differ across racial groups.DESIGNTwo site qualitative study.METHODSEleven focus groups were conducted in 2007 with 51 Black and 55 White adult participants in Montgomery, AL and Baltimore, MD.MEASUREMENTSQuestions were asked about smoking as an addiction, the role of genetics in nicotine addiction susceptibility, and undergoing genetic testing to receive tailored smoking cessation treatment. Data were analyzed using content analysis.FINDINGSMost participants believed that smoking was an addiction yet were unwilling to endorse the notion that genetics played a role in nicotine addiction susceptibility. However, 91% of White participants and 62% of Black participants indicated that they would likely take a genetic test that would match them to their optimal smoking cessation treatment. The primary potential benefit was a vague sense that additional knowledge about oneself would be of value. Primary barriers included disinterest and skepticism about the test, unwillingness to believe that genetics played a role in nicotine addiction or treatment response, and concerns about psychological consequences.CONCLUSIONSThe majority of participants, particularly Black participants, did not believe that genetics played a significant role in nicotine addiction susceptibility but were willing to undergo genetic testing. Participants identified some benefit to tailoring smoking treatment by genotype. However, participants also expressed skepticism about the test and concerns about its consequences; these issues would need to be addressed in the clinical encounter.