Epithelial ovarian cancer
Epithelial ovarian cancer
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DOI：
10.1007/978-1-59259-768-0_35
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发表时间：
2018-06
期刊：
影响因子：
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通讯作者：
Kristin K. Zorn;Ginger J. Gardner;Michael J. Birrer
中科院分区：
文献类型：
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作者：
Kristin K. Zorn;Ginger J. Gardner;Michael J. Birrer
上皮性卵巢癌在所有妇科癌症中死亡率最高（1）。大多数患者被诊断为晚期疾病，因此预后不良（1）。尽管在过去的几十年里，卵巢癌的手术方法和化疗方案取得了进展，但5年生存率基本保持不变，为30%（2）。由于治疗晚期卵巢癌的困难，现在越来越多的注意力集中在预防这种毁灭性的疾病上。本章讨论的问题，阻碍了化学预防的努力，以及一些最近的进展，可能提供解决方案。
Epithelial ovarian cancer has the highest mortality rate of all gynecologic cancers (1). The majority of patients are diagnosed with advanced-stage disease and consequently have a poor prognosis (1). Despite progress in surgical approaches and chemotherapeutic regimens for ovarian cancer during the last several decades, 5-yr survival rates remain essentially unchanged at 30% (2). Due to the difficulty in treating advanced-stage ovarian carcinoma, increased attention is now focused on preventing this devastating disease. This chapter discusses problems that have hindered chemoprevention efforts as well as some recent advances that may provide solutions.