Symptoms, clusters and quality of life prior to surgery for breast cancer
Symptoms, clusters and quality of life prior to surgery for breast cancer
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DOI：
10.1111/jocn.12430
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发表时间：
2014-09-01
影响因子：
4.2
通讯作者：
Gooney, Martina
中科院分区：
文献类型：
--
作者：
Denieffe, Suzanne;Cowman, Seamus;Gooney, Martina
目的和目标。检查等待乳腺癌手术的女性正在经历的治疗前症状和症状群，以及这些症状对她们生活质量的影响。背景。大多数被诊断患有乳腺癌的女性都会将手术作为一线治疗。术前症状的存在可能会导致痛苦和生活质量受损。虽然似乎患有乳腺癌的女性可能会出现疲劳、疼痛、抑郁和睡眠障碍等症状，但这一点尚未得到术前时期的实证研究的证实。使用多点前瞻性纵向队列面板设计。方法。使用医院焦虑和抑郁量表、失眠严重程度指数、癌症治疗疲劳功能评估、简要疼痛量表和欧洲癌症研究和治疗组织生活质量问卷核心 30(3) 来评估术前症状和生活质量。结果。参与者（n = 94，年龄范围 30-92）在手术前出现过症状，其中疼痛（35%）比疲劳（32%）、睡眠障碍（25.5%）或抑郁（11%）更普遍。整体生活质量受到疲劳的显着影响，与情绪功能呈中度相关，与身体和社会功能呈弱相关。分层聚类分析确定存在五个聚类，每个聚类中存在不同强度的症状。结论。在这组女性中，除了被诊断出患有乳腺癌之外，身体健康，症状正在影响生活质量。很明显，术前存在一系列症状，必须对其进行评估和管理。与实践的相关性。医疗保健服务系统必须确保早期症状在术前得到有效解决，以提高生活质量并减少术后不良后果。
Aims and objectives. To examine the pretreatment symptoms and symptom clusters that women awaiting breast cancer surgery are experiencing and the impact of these symptoms on their quality of life.Background. Most women diagnosed with breast cancer will have surgery as a first-line treatment. The presence of presurgery symptoms may be significant in contributing to distress and impaired quality of life. While it seems that women with breast cancer may experience the symptoms of fatigue, pain, depression and sleep disturbance as a cluster, this has not yet been confirmed by empirical research in the presurgery time period.Design. A multiple-point prospective longitudinal cohort panel design is used.Methods. Presurgery symptoms and quality of life were assessed using the Hospital Anxiety and Depression Scale, Insomnia Severity Index, Functional Assessment of Cancer Therapy-Fatigue, Brief Pain Inventory and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30(3).Results. Participants (n = 94, age range 30-92) experienced symptoms prior to surgery, with pain being a more prevalent symptom (35%) than fatigue (32%), sleep disturbances (25.5%) or depression (11%). global quality of life was significantly impacted on by fatigue and showed a moderate correlation with emotional functioning and a weak correlation with physical and social functioning. Hierarchical cluster analysis identified the presence of five clusters with symptoms present in differing intensities in each cluster.Conclusion. In this cohort of women, healthy other than having a diagnosis of breast cancer, symptoms were impacting on quality of life. It is evident that clusters of symptoms are present presurgery that must be assessed and managed.Relevance to practice. Healthcare delivery systems must ensure that early symptoms are addressed effectively in the presurgery period to improve quality of life and reduce adverse outcomes postsurgery.