The Utility of Cannabidiol in the Treatment of Refractory Epilepsy
The Utility of Cannabidiol in the Treatment of Refractory Epilepsy
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大麻二酚在治疗难治性癫痫中的用途
DOI：
10.1002/cpt.441
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发表时间：
2017
影响因子：
6.7
通讯作者：
D. Reddy
中科院分区：
文献类型：
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作者：
D. Reddy
大麻衍生的大麻素，如大麻二酚 (CBD) 具有抗惊厥特性。最近，人们对使用富含 CBD 的产品治疗耐药性癫痫产生了浓厚的兴趣。 CBD 的一些试点试验已证明对难治性癫痫有益，但其疗效尚未得到标准安慰剂对照试验的证实。然而，CBD 的癫痫保护功效声称背后的机制仍不清楚。本综述简要描述了 CBD 在治疗难治性癫痫中的临床效用。
Cannabis‐derived cannabinoids such as cannabidiol (CBD) have anticonvulsant properties. Recently, there has been an emerging interest in the use of CBD‐enriched products for treatment of drug‐resistant epilepsy. Some pilot trials of CBD have proved beneficial for refractory epilepsy, but its efficacy is yet to be confirmed by standard placebo‐controlled trials. However, the mechanisms underlying the seizure protection efficacy claims of CBD remain unclear. This review briefly describes the clinical utility of CBD in the treatment of refractory epilepsy.