Novel and efficient synthesis of difficult sequence-containing peptides through O-N intramolecular acyl migration reaction of O-acyl E isopeptides
Novel and efficient synthesis of difficult sequence-containing peptides through O-N intramolecular acyl migration reaction of O-acyl E isopeptides
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DOI：
10.1039/b312129a
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发表时间：
2004-01-07
影响因子：
4.9
通讯作者：
Kiso, Y
中科院分区：
文献类型：
--
作者：
Sohma, Y;Sasaki, M;Kiso, Y
在合成o -酰基异肽后进行O-N酰基分子内迁移反应的基础上，提出了一种新的高效合成难序多肽的方法，从而显著提高了产率。
A novel and efficient method for the synthesis of difficult sequence-containing peptides has been developed based on the synthesis of O-acyl isopeptides followed by an O-N intramolecular acyl migration reaction, resulting in a remarkable improvement of the yields.