Resting-state functional connectivity of the anterior cingulate cortex in young adults depressed patients with and without suicidal behavior
Resting-state functional connectivity of the anterior cingulate cortex in young adults depressed patients with and without suicidal behavior
复制标题
有或没有自杀行为的年轻抑郁症患者前扣带皮层的静息态功能连接
DOI：
10.1016/j.bbr.2020.112544
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发表时间：
2020-04-20
影响因子：
2.7
通讯作者：
Kuang, Li
中科院分区：
文献类型：
--
作者：
Qiu, Haitang;Cao, Bo;Kuang, Li
在重度抑郁症（MDD）患者的前扣带皮层（ACC）的亚区域的功能改变已被观察到。研究表明，较高的抑郁症状与不同ACC子区域的功能连接（FC）改变有关。自杀在MDD患者中非常普遍;然而，尚不清楚自杀行为是否与这些患者ACC亚区的FC改变相关。76例MDD患者（41例有自杀行为史，35例无自杀行为史）接受功能性磁共振成像（fMRI），并使用汉密尔顿抑郁量表（HAMD）、自杀意念量表（SSI）和哥伦比亚自杀严重程度量表进行评估。我们调查了有和没有自杀行为史的年轻MDD患者的ACC亚区和其他脑区之间的FC。两组ACC-额上回各亚区的FC差异有统计学意义。此外，在自杀性MDD组中发现前sgACC-右尾状核FC和pgACC-左尾状核FC异常。有趣的是，在两组中，自杀意念评分与pgACC-额上回的FC降低呈正相关，但在非自杀MDD组中，自杀意念评分与前sgACC-额上回的FC增加呈负相关。我们的研究结果表明，改变连接的次区域在前扣带回可能参与的神经机制自杀的年轻人与抑郁症。
Functional alterations in the subregions of the anterior cingulate cortex (ACC) have been observed in patients with major depressive disorder (MDD). Studies have shown that higher depressive symptoms are associated with altered functional connectivity (FC) in different ACC sub-regions. Suicide is highly prevalent in patients with MDD; however, it is unclear whether suicidal behavior is associated with the FC alterations in the subregions of the ACC in these indibiduals. Seventy-six patients with MDD (41 with and 35 without a history of suicidal behavior) underwent functional magnetic resonance imaging (fMRI) and were assessed using the Hamilton Rating Scale for Depression (HAMD), the Scale for Suicide Ideation (SSI), and the Columbia Scale for Rating of Suicide Severity. We investigated the FC between the ACC subregions and other brain regions in young MDD patients with and without a history of suicidal behavior. The FC in the subregions of the ACC-superior frontal gyrus differed significantly between the two groups. Additionally, the anterior sgACC-right caudate FC and the pgACC-left insula FC were found to be abnormal in the suicidal MDD group. Interestingly, the suicidal ideation score positively correlated with decreased FC in the pgACC-superior frontal gyrus in both groups, but it negatively correlated with increased FC in the anterior sgACC-superior frontal gyrus in the non-suicidal MDD group. Our findings indicate that altered connections of subregions in the ACC may be involved in the neurological mechanisms underlying suicide in young adults with MDD.