Biomechanical Performances of Networked Polyethylene Glycol Diacrylate: Effect of Photoinitiator Concentration, Temperature, and Incubation Time.
Biomechanical Performances of Networked Polyethylene Glycol Diacrylate: Effect of Photoinitiator Concentration, Temperature, and Incubation Time.
复制标题
网络聚乙烯乙二醇二丙烯酸酯的生物力学性能：光引发剂浓度，温度和孵育时间的影响。
DOI：
10.1155/2016/3208312
复制
发表时间：
2016
影响因子：
3.1
通讯作者：
Yasar O
中科院分区：
文献类型：
--
作者：
Khandaker M;Orock A;Tarantini S;White J;Yasar O
可以在聚乙二醇二丙烯酸酯（PEGDA）组织构建体内引入营养导管网络，以使细胞能够在支架中存活。营养物管道网络可以通过宏通道到纳米通道制造技术在PEGDA上产生。这种网络可以影响PEGDA支架的机械和细胞活性。没有进行研究来评估营养导管网络对组织支架的最大拉伸应力和细胞活性的影响。本研究旨在探讨网络结构对PEGDA支架最大拉伸应力的影响，并与非网络化PEGDA支架进行比较。我们的研究发现，在23 ° C和37 ° C的温度条件下，由于将营养导管网络引入PEGDA支架，最大拉伸应力分别降低了1.78和2.23倍。该研究还发现网络结构、PI浓度、温度和等待时间对PEGDA样品的最大破坏应力的统计学显著影响（P值<0.05）。细胞活力的结果表明，网络化的PEGDA水凝胶具有增加的活力相比，nonnetworked和降低的活力与光引发剂浓度。本研究结果可用于设计具有大尺寸营养导管网络通道的PEGDA支架。
Nutrient conduit networks can be introduced within the Polyethylene Glycol Diacrylate (PEGDA) tissue construct to enable cells to survive in the scaffold. Nutrient conduit networks can be created on PEGDA by macrochannel to nanochannel fabrication techniques. Such networks can influence the mechanical and cell activities of PEGDA scaffold. There is no study conducted to evaluate the effect of nutrient conduit networks on the maximum tensile stress and cell activities of the tissue scaffold. The study aimed to explore the influence of the network architecture on the maximum tensile stress of PEGDA scaffold and compared with the nonnetworked PEGDA scaffold. Our study found that there are 1.78 and 2.23 times decrease of maximum tensile stress due to the introduction of nutrient conduit networks to the PEGDA scaffold at 23°C and 37°C temperature conditions, respectively. This study also found statistically significant effect of network architecture, PI concentration, temperature, and wait time on the maximum failure stress of PEGDA samples (P value < 0.05). Cell viability results demonstrated that networked PEGDA hydrogels possessed increased viability compared to nonnetworked and decreased viability with increased photoinitiator concentrations. The results of this study can be used for the design of PEGDA scaffold with macrosize nutrient conduit network channels.