PURGATIVE ACTIVITY AND PRINCIPALS OF THE FRUITS OF ROSA-MULTIFLORA AND R-WICHURAIANA
PURGATIVE ACTIVITY AND PRINCIPALS OF THE FRUITS OF ROSA-MULTIFLORA AND R-WICHURAIANA
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DOI：
10.1248/cpb.40.2080
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发表时间：
1992-08-01
影响因子：
1.7
通讯作者：
AKIYAMA, K
中科院分区：
文献类型：
--
作者：
SETO, T;YASUDA, I;AKIYAMA, K
假鲤鱼或多花蔷薇的种子，生药“Eijitsu”（原文如此），在日本传统医学中被用作泻药。人们普遍认为，白藜芦醇可以替代这种植物。两种植物种子正丁醇组分对小鼠的泻泻作用测定结果表明，50%有效剂量（ED50）为多花蒿种子重5.6 g/kg，木香蒿种子重57 g/kg。从多花假鲤中分离到一种新的泻剂——醋酸多苷a，其ED50值为150 mg/kg （77 ~ 291 mg/kg， 95%置信限）。其他分离得到的化合物为槲皮素糖苷、槲皮素3- o -木糖苷、异槲皮苷和金丝桃苷。从黄颡鱼中分离到槲皮素苷、异槲皮苷、金丝桃苷和槲皮素3- o - β - d -葡糖苷，但未检出多花黄颡鱼的泻性成分。
Pseudocarps or seeds of Rosa multiflora, crude drug "Eijitsu" (sic), have been used as purgative in Japanese traditional medicine. R. wichuraiana was generally thought to be able to substitute for the plant. The n-butanol fractions of both plant seeds were tested on purgative activities with mice, and the values of the 50% effective dose (ED50) were 5.6 g/kg as the seed weight for R. multiflora and 57 g/kg as the seed weight for R. wickuraiana. From pseudocarps of R. multiflora, a new purgative compound, multinoside A acetate, was isolated, and its ED50 value was tested to be 150 mg/kg (77-291 mg/kg, 95% confidence limit). The other isolated compounds were three known quercetin glycosides, quercetin 3-O-xyloside, isoquercitrin and hyperin. From pseudocarps of R. wichuraiana, three quercetin glycosides, isoquercitrin, hyperin and quercetin 3-O-beta-D-glucuronide were isolated similarly, but no purgative components of R. multiflora were detected.