Loss of chromosome Y in blood, but not in brain, of suicide completers.
Loss of chromosome Y in blood, but not in brain, of suicide completers.
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DOI：
10.1371/journal.pone.0190667
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Sora I
中科院分区：
文献类型：
--
作者：
Kimura A;Hishimoto A;Otsuka I;Okazaki S;Boku S;Horai T;Izumi T;Takahashi M;Ueno Y;Shirakawa O;Sora I
男性自杀完成率高于女性，这表明性染色体异常可能与自杀的病理生理学有关。最近的研究发现，在各种疾病中Y染色体（LOY）的异常丢失;然而，没有研究调查LOY和自杀之间是否存在关联。本研究的目的是确定LOY是否发生在自杀完成的男性中。我们的研究包括286名日本男性受试者，其中包括140名没有严重身体疾病的自杀完成者（130份外周血和10份大脑死后样本）和146名年龄匹配的对照受试者（130份健康个体的外周血样本和16份死后大脑样本）。LOY被测量为来自Y-X同源釉原蛋白基因（AMELY和AMELX）的共扩增短序列的荧光信号的Y染色体/X染色体比率。回归分析表明，LOY在自杀完成者的血液中比对照组中发现的频率更高（比值比= 3.50，95%置信区间= 1.21-10.10），但不是在背外侧前额叶皮层（DLPFC）区域的大脑。健康对照组LOY值与年龄相关性正常（r =-0.353，p = 0.001），自杀完成者LOY值与年龄相关性正常（r =-0.119，p = 0.177）。DLPFC组织具有年龄依赖性LOY（B =-0.002，p = 0.015），其与表型无关。据我们所知，这是第一项研究表明血液中的LOY与自杀完成有关。此外，我们的研究结果也首次表明，年龄依赖性LOY不仅可能发生在血液中，也可能发生在特定的大脑区域。
Men have a higher rate of completed suicide than women, which suggests that sex chromosome abnormalities may be related to the pathophysiology of suicide. Recent studies have found an aberrant loss of chromosome Y (LOY) in various diseases; however, no study has investigated whether there is an association between LOY and suicide. The purpose of this study was to determine whether LOY occurs in men who completed suicide. Our study consisted of 286 male Japanese subjects comprised of 140 suicide completers without severe physical illness (130 post-mortem samples of peripheral blood and 10 brains) and 146 age-matched control subjects (130 peripheral blood samples from healthy individuals and 16 post-mortem brains). LOY was measured as the chromosome Y/chromosome X ratio of the fluorescent signal of co-amplified short sequences from the Y-X homologous amelogenin genes (AMELY and AMELX). Regression analyses showed that LOY in the blood of suicide completers was significantly more frequent than that found in controls (odds ratio = 3.50, 95% confidence interval = 1.21–10.10), but not in the dorsolateral prefrontal cortex (DLPFC) region of brain. Normal age-dependent LOY in blood was found in healthy controls (r = -0.353, p < 0.001), which was not seen in suicide completers (r = -0.119, p = 0.177). DLPFC tissue had age-dependent LOY (B = -0.002, p = 0.015), which was independent of phenotype. To our knowledge, this is the first study demonstrating that LOY in blood is associated with suicide completion. In addition, our findings are the first to also indicate that age-dependent LOY may occur not only in blood, but also in specific brain regions.
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DOI：
10.1038/nrendo.2010.186
发表时间：
2010-12
期刊：
Nature reviews. Endocrinology
影响因子：
--
作者：
通讯作者：
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影响因子：
9.8
作者：
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影响因子：
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作者：
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通讯作者：
Hishimoto A
DOI：
10.3390/ijerph9030760
发表时间：
2012-03
影响因子：
--
作者：
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通讯作者：
Värnik P
DOI：
10.1016/s0197-2456(98)00037-3
发表时间：
1998-12-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
Dupont, WD;Plummer, WD
通讯作者：
Plummer, WD