Serum Lipid Hydroperoxide Levels and Paraoxonase Activity in Patients With Lung, Breast, and Colorectal Cancer
Serum Lipid Hydroperoxide Levels and Paraoxonase Activity in Patients With Lung, Breast, and Colorectal Cancer
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DOI：
10.1002/jcla.21503
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发表时间：
2012-01-01
影响因子：
2.7
通讯作者：
Uzun, H.
中科院分区：
文献类型：
--
作者：
Balci, H.;Genc, H.;Uzun, H.
目的探讨肺癌、乳腺癌和结直肠癌患者血清脂质过氧化氢（LOOH）水平及对氧磷酶-1（PON 1）和芳基酯酶（ARE）活性的变化。设计与方法：检测110例恶性肿瘤患者和110例年龄、性别相匹配的对照组血清PON 1、ARE活性和LOOH水平。结果与对照组相比，患者血清LOOH水平升高，血清PON 1和ARE活性降低。PON 1活性在乳腺癌患者中低于肺癌和结直肠癌患者。大肠癌患者血清PON 1与ARE活性呈正相关。结论PON 1、ARE活性降低和LOOH水平升高可能与胃癌的发生有关。所有患者的PON 1活性均降低，但除结直肠癌外，它似乎与转移状态无关。J. Clin. Lab. Anal. 26：155-160，2012. (c)2012 Wiley Periodicals，Inc.
Objectives The objectives of this article are to investigate the serum lipid hydroperoxide (LOOH) levels and paraoxonase-1 (PON1) and arylesterase (ARE) activity in patients with lung, breast, and colorectal cancer. Design and methods Serum PON1 and ARE activities and LOOH levels were measured in 110 patients with cancer and same number of age- and sex-matched controls. Results Serum LOOH levels were found to be increased while serum PON1 and ARE activities were found to be decreased in patients compared to controls. PON1 activity was found to be lower in patients with breast cancer than in patients with lung and colorectal cancer. There were positive correlations between the serum PON1 and ARE activities in patients with colorectal cancer. Conclusion We concluded that decreased PON1 and ARE activities and increased LOOH levels might have a connection to carcinogenesis. PON1 activity is decreased in all patients but it does not seem to be related to metastase status except for colorectal cancer. J. Clin. Lab. Anal. 26:155-160, 2012. (c) 2012 Wiley Periodicals, Inc.