Accelerated repletion of ATP and GTP pools in postischemic canine myocardium using a precursor of purine de novo synthesis.
Accelerated repletion of ATP and GTP pools in postischemic canine myocardium using a precursor of purine de novo synthesis.
复制标题
使用嘌呤从头合成的前体加速犬缺血后心肌中 ATP 和 GTP 库的补充。
DOI：
10.1161/01.res.51.1.102
复制
发表时间：
1982
影响因子：
20.1
通讯作者：
Holmes,EW
中科院分区：
文献类型：
--
作者：
Swain,JL;Hines,JJ;Sabina,RL;Holmes,EW
在缺血期间，心肌中嘌呤核苷酸ATP和GTP的含量下降，并持续数小时到数天的低迷状态。缺血后ATP的长期耗竭伴随着功能和超微结构的异常。本报告描述了嘌呤前体5-氨基咪唑-4-甲酰胺核苷选择性地提高缺血后心肌中ATP和GTP池的充盈率。
During ischemia, the myocardial content of the purine nucleotides ATP and GTP falls and remains depressed for hours to days. Prolonged depletion of ATP in the postischemic state is accompanied by functional and ultrastructural abnormalities. This report describes the successful use of the purine precursor 5-aminoimidazole-4-carboxamide riboside to selectively enhance the rate of repletion of the ATP and GTP pools in postischemic myocardium.