Basic aspects of musculoskeletal pain: from acute to chronic pain
Basic aspects of musculoskeletal pain: from acute to chronic pain
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DOI：
10.1179/106698111x13129729551903
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发表时间：
2011-01-01
影响因子：
2
通讯作者：
Graven-Nielsen, Thomas
中科院分区：
文献类型：
--
作者：
Arendt-Nielsen, Lars;Fernandez-de-las-Penas, Cesar;Graven-Nielsen, Thomas
从急性肌肉骨骼疼痛到慢性肌肉骨骼疼痛的转变还不是很清楚。要理解这一转变，重要的是要知道外周和中枢敏化是如何表现出来的，以及如何评估它们。各种人类疼痛生物标记物已被开发用于量化局部和广泛的肌肉骨骼疼痛。此外，人类代理模型可能被用来在其他健康的志愿者中诱导致敏。疼痛可以由不同的肌肉骨骼结构(如肌肉、关节、韧带或肌腱)引起，区分这些不同结构的疼痛来源是一个挑战。组织特异性疼痛生物标记物可以用来戏弄这些不同的方面。慢性肌肉骨骼疼痛患者一般表现出局部/中枢敏感化的迹象，疼痛扩散到与疼痛强度和持续时间相关的程度。因此，从管理的角度来看，降低疼痛强度并尽量减少疼痛持续时间是非常重要的。
The transition from acute to chronic musculoskeletal pain is not well understood. To understand this transition, it is important to know how peripheral and central sensitization are manifested and how they can be assessed. A variety of human pain biomarkers have been developed to quantify localized and widespread musculoskeletal pain. In addition, human surrogate models may be used to induce sensitization in otherwise healthy volunteers. Pain can arise from different musculoskeletal structures (e.g. muscles, joints, ligaments, or tendons), and differentiating the origin of pain from those different structures is a challenge. Tissue specific pain biomarkers can be used to tease these different aspects. Chronic musculoskeletal pain patients in general show signs of local/central sensitization and spread of pain to degrees which correlate to pain intensity and duration. From a management perspective, it is therefore highly important to reduce pain intensity and try to minimize the duration of pain.