Effects of low-dose gamma-irradiation to the chest regions on the blood pressure of spontaneous hypertensive rats.
Effects of low-dose gamma-irradiation to the chest regions on the blood pressure of spontaneous hypertensive rats.
复制标题
胸部低剂量伽玛射线照射对自发性高血压大鼠血压的影响。
DOI：
--
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
K. Ishii
中科院分区：
文献类型：
--
作者：
K. Yamaoka;K. Ishii
我们检查了对自发性高血压大鼠（SHR）和Wistar京都大鼠（WKY）胸部进行γ射线照射后血压和主动脉组织中超氧化物歧化酶（SOD）活性的变化，并获得了以下结果。 5 Gy 照射后，WKY 大鼠的血压随时间没有变化，而 SHR 大鼠则观察到短暂的下降（3 天后）。 SHR主动脉Cu/Zn-SOD活性低于WKY。 5 Gy 辐照诱导 SHR 中的 Cu/Zn-SOD 活性增加，几乎达到 WKY 中观察到的水平，且辐照后保持不变。因此，与高剂量照射不同，对 SHR 进行 5 Gy 相对低剂量的照射似乎会增加 SHR 所缺乏的主动脉 Cu/Zn-SOD 活性，从而导致血压下降。
We examined changes in the blood pressure and the superoxide dismutase (SOD) activities in aortic tissue after gamma-irradiation to the chest regions of spontaneous hypertensive rats (SHR) and Wistar Kyoto rats (WKY), and obtained the following results. After 5 Gy irradiation, there was no change with time in the blood pressure in WKY rats, while a transient decrease (3 days later) was observed in SHR rats. The Cu/Zn-SOD activity in the aorta of SHR was less than that of WKY. 5 Gy irradiation induced an increase in the Cu/Zn-SOD activity in SHR nearly to the level observed in WKY, which remained unchanged upon irradiation. Therefore, unlike high-dose irradiation, irradiation at a relatively low-dose of 5 Gy to SHR appears to increase the aortic Cu/Zn-SOD activity, which is lacking in SHR, leading to a decrease in the blood pressure.