Extraction and encapsulation of prodigiosin in chitosan rnicrospheres for targeted drug delivery
Extraction and encapsulation of prodigiosin in chitosan rnicrospheres for targeted drug delivery
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DOI：
10.1016/j.msec.2016.09.078
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发表时间：
2017-02-01
影响因子：
7.9
通讯作者：
Soboyejo, W. O.
中科院分区：
文献类型：
--
作者：
Dozie-Nwachukwu, S. O.;Danyuo, Y.;Soboyejo, W. O.
高分子材料中药物的包封为化疗药物的靶向递送带来了机会。这些聚合物传递系统能够最大限度地提高治疗活性，并减少抗癌药物的副作用。从粘质沙雷氏菌中提取的次级代谢物，显示出抗癌特性。以戊二醛为交联剂，采用油包水（w/o）乳液法制备了负载菌素的壳聚糖微球，并用扫描电镜对微球的形貌进行了研究。微球的平均粒径为40 ~ 60 pm，产率为42 +/- 2% ~ 55.5 +/- 3%。包封效率在66.7 +/- 3% ~ 90 +/- 4%之间。通过零阶、一阶和Higuchi and kimmeyer - peppas (C) 2016 Elsevier B.V.对微球体外药物释放进行表征。
The encapsulation of drugs in polymeric materials has brought opportunities to the targeted delivery of chemotherapeutic agents. These polymeric delivery systems are capable of maximizing the therapeutic activity, as well as reducing the side effects of anti-cancer agents. Prodigiosin, a secondary metabolite extracted from the bacteria, Serratia marcescens, exhibits anti-cancer properties. Proffigiosin-loaded chitosan microspheres were prepared via water-in-oil (w/o) emulsion technique, using glutaraldehyde as a cross-linker, The morphologies of the micro spheres were studied using scanning electron microscopy. The average sizes of the microspheres were between 40 pm and 60 pm, while the percentage yields ranged from 42 +/- 2% to 55.5 +/- 3%. The resulting encapsulation efficiencies were between 66.7 +/- 3% and 90 +/- 4%. The in-vitrp drug release from the microspheres was characterized by zeroth order, first order and Higuchi and Kmmeyer-Peppas (C) 2016 Elsevier B.V. All rights reserved.