Abuse of prescription drugs and the risk of addiction
Abuse of prescription drugs and the risk of addiction
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DOI：
10.1016/j.drugalcdep.2005.10.020
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发表时间：
2006-06-01
影响因子：
4.2
通讯作者：
Volkow, Nora D.
中科院分区：
文献类型：
--
作者：
Compton, Wilson A.;Volkow, Nora D.
在过去十年中，美国滥用几类处方药的情况明显增加，某些制剂，特别是类阿片镇痛剂和兴奋剂，目前已达到令人震惊的程度。滥用的处方药与非处方药属于相同的药理学类别。因此，与这些药物的滥用或成瘾与安全治疗使用相关的潜在因素与预期变量有关：剂量、给药途径、与其他药物联合给药、使用背景和预期。今后关于处方药滥用的科学工作将包括确定最大限度地减少成瘾风险的临床做法，制定早期发现和管理成瘾的准则，以及开发最大限度地减少滥用风险的临床有效药剂。由于美国青少年滥用处方药的比例很高，一个特别紧迫的优先事项是调查有效预防和治疗青少年的最佳做法，以及制定战略减少医疗用途药物的转移和滥用。出版社：Elsevier爱尔兰Ltd.
Abuse of several categories of prescription drugs has increased markedly in the United States in the past decade and is now at alarming levels for certain agents, especially opioid analgesics and stimulants. Prescription drugs of abuse fit into the same pharmacological classes as their non-prescription counterparts. Thus, the potential factors associated with abuse or addiction versus safe therapeutic use of these agents relates to the expected variables: dose, route of administration, co-administration with other drugs, context of use, and expectations. Future scientific work on prescription drug abuse will include identification of clinical practices that minimize the risks of addiction, the development of guidelines for early detection and management of addiction, and the development of clinically effective agents that minimize the risks for abuse. With the high rates of prescription drug abuse among teenagers in the United States, a particularly urgent priority is the investigation of best practices for effective prevention and treatment for adolescents, as well as the development of strategies to reduce diversion and abuse of medications intended for medical use. Published by Elsevier Ireland Ltd.