Carcinogenesis driven by bone marrow-derived stem cells
Carcinogenesis driven by bone marrow-derived stem cells
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DOI：
10.1159/000092971
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发表时间：
2006-01-01
期刊：
影响因子：
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通讯作者：
Niggemann, Bernd
中科院分区：
文献类型：
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作者：
Dittmar, Thomas;Seidel, Jeanette;Niggemann, Bernd
骨髓源性干细胞（BMDC）转分化的总体机制似乎很简单：BMDC根据组织本身提供的蓝图进行转分化。因此，蓝图可以是局部组织微环境（由组织特异性细胞因子、趋化因子、粘附分子模式等限定），它可以是单个细胞（细胞融合），或者它可以是两者的组合。事实上，干细胞转分化是一个复杂的尚未完全理解的过程。在转分化的起始点和终止点之间，几个基因重编程步骤必须以连续的逐步方式发生，为此，定义的一组指令是确保准确转分化的先决条件。然而，最近的一项研究表明，BMDC通过阅读其蓝图来适应组织功能的能力似乎是一把双刃剑，因为BMDC接收到由慢性炎症组织提供的错误蓝图，转分化为肿瘤表型。在这里，我们回顾了BMDC转分化的准确蓝图的重要性，并讨论了一个模型，显示BMDC可能有助于整体肿瘤的发展，由于招聘到肿瘤组织。
The overall mechanism of bone marrow-derived stem cell (BMDC) trans-differentiation seems to be simple: BMDCs trans-differentiate as referred to the blueprint, which is given by the tissue itself. Thereby, the blueprint can be the local tissue micro-environment (defined by the tissue-specific cytokine, chemokine, adhesion molecule pattern, etc.), it can be a single cell (cell fusion), or it can be a combination of both. In fact stem cell trans-differentiation is a complex not yet fully understood process. In between the start-and stop-points of transdifferentiation several gene reprogramming steps have to occur in a sequential step-by-step manner, for which a defined set of instructions is a prerequisite to ensure an accurate transdifferentiation. However, a recent study indicated that the ability of BMDCs–to adopt tissue function by reading its blueprint–seems to be a double-edged sword since BMDCs that have received a faulty blueprint, provided by chronically inflamed tissue, trans-differentiated into a neoplastic phenoytpe. Here, we review the importance of an accurate blueprint for BMDC trans-differentiation and discuss a model showing that BMDCs might contribute to overall tumor development due to recruitment to tumor tissue.