Determination of Urinary 1-Hydroxypyrene for Biomonitoring of Human Exposure to Polycyclic Aromatic Hydrocarbons Carcinogens by a Lanthanide- functionalized Metal-Organic Framework Sensor
Determination of Urinary 1-Hydroxypyrene for Biomonitoring of Human Exposure to Polycyclic Aromatic Hydrocarbons Carcinogens by a Lanthanide- functionalized Metal-Organic Framework Sensor
复制标题
通过镧系元素功能化金属有机骨架传感器测定尿 1-羟基芘，用于人体接触多环芳烃致癌物的生物监测
DOI：
10.1002/adfm.201603856
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发表时间：
2017-02-10
影响因子：
19
通讯作者：
Yan, Bing
中科院分区：
文献类型：
--
作者：
Hao, Ji-Na;Yan, Bing
1-羟基芘（1-HP）是多环芳烃（PAHs）致癌物的生物标志物，代表人体暴露于PAHs的内剂量，通过一种新设计的发光eu功能化金属有机框架（1a）传感器进行检测。1a的发光可以通过荧光共振能量转移过程被1-HP有效猝灭，从而实现其对1-HP的识别。这是首次使用镧系金属有机框架（Ln-MOFs）作为1-HP的化学传感器。该探针具有高选择性、高灵敏度、快速响应和良好的可重用性等特点。重要的是，该传感系统能够检测真实人类尿液样本中的1-HP，并且还开发了便携式1-HP尿液试纸。因此，所报道的1-HP传感平台在临床诊断多环芳烃中毒水平方面具有很大的应用潜力。
1-Hydroxypyrene (1-HP), which is a biomarker of polycyclic aromatic hydrocarbons (PAHs) carcinogens and represents the internal dose of PAHs exposure in the human body, is detected by a newly designed luminescent Eu-functionalized metal-organic framework (1a) sensor. The luminescence of 1a can be effectively quenched by 1-HP via a fluorescent resonant energy transfer process, thus achieving its recognition of 1-HP. This is the first use of lanthanide metal-organic frameworks (Ln-MOFs) as chemical sensors for 1-HP. The probe exhibits outstanding performances for sensing 1-HP, such as high selectivity, excellent sensitivity, fast response, and good reusability. Importantly, the sensing system enables the detection of 1-HP in real human urine specimens, and a portable 1-HP urine test paper is also developed. Hence, the reported 1-HP sensing platform has promising application potential for clinical diagnosis of the intoxication level of PAHs.