Electromechanical limits of polymersomes
Electromechanical limits of polymersomes
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DOI：
10.1103/physrevlett.87.208301
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发表时间：
2001-11-12
影响因子：
8.6
通讯作者：
Discher, DE
中科院分区：
文献类型：
--
作者：
Aranda-Espinoza, H;Bermudez, H;Discher, DE
两亲性二嵌段共聚物的自组装膜使得能够在疏水厚度d = 3-15 nm的范围内与脂质膜进行内聚性的比较。在零机械张力下，d = 15 mn的聚合物囊泡的击穿电位V-c为9 V，而d = 3 mn的脂质体为1 V。尽管如此，击穿时的机电应力普遍表现出V-c（2）依赖性，膜电容显示出预期的强d依赖性，符合简单的热力学模型。二嵌段膜的粘性性质在持久的穿孔后动力学中是明显的。
Self-assembled membranes of amphiphilic diblock copolymers enable comparisons of cohesiveness with lipid membranes over the range of hydrophobic thicknesses d = 3-15 nm. At zero mechanical tension the breakdown potential V-c for polymersomes with d = 15 mn is 9 V, compared to 1 V for liposomes with d = 3 mn. Nonetheless, electromechanical stresses at breakdown universally exhibit a V-c(2) dependence, and membrane capacitance shows the expected strong d dependence, conforming to simple thermodynamic models. The viscous nature of the diblock membranes is apparent in the protracted postporation dynamics.