Helicobacter pylori typing as a tool for tracking human migration.
Helicobacter pylori typing as a tool for tracking human migration.
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DOI：
10.1111/j.1469-0691.2009.02967.x
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发表时间：
2009-09
期刊：
影响因子：
--
通讯作者：
Yamaoka Y
中科院分区：
文献类型：
--
作者：
Yamaoka Y
来自不同地理区域的幽门螺杆菌菌株表现出明显的系统地理分化，因此，幽门螺杆菌菌株的基因分型可以作为人类种群迁移的标志。目前，幽门螺杆菌两种毒力因子cagA和VacA的基因分型和多位点序列分型(MLST)是幽门螺杆菌种群基因组多样性的广泛应用标记。有两种类型的cagA：东亚型和西方型。此外，CAG致病岛的右端分为5个亚型，在VacA的信号区和中间区有明显的镶嵌结构。利用cagA、CAG右端连接和VacA基因的组合，根据地理关联定义了五个主要群体(东亚类型、南亚/中亚类型、伊比利亚/非洲类型和欧洲类型)。MLST揭示了幽门螺杆菌的7种现代种群类型和6种祖先种群类型，是绘制人类迁移模式的有用工具。对大量幽门螺杆菌菌株的系列研究表明，与人类遗传学分析相比，MLST分析提供了关于人类迁徙的更详细的信息。由于个人卫生和生活质量的改善，幽门螺杆菌感染正在迅速下降。幽门螺杆菌感染的分子流行病学告诉我们很多，应该在它完全消失之前进行研究。
Helicobacter pylori strains from different geographic areas exhibit clear phylogeographical differentiation; therefore, the genotypes of H. pylori strains can serve as markers for the migration of human populations. Currently, the genotypes of two virulence factors of H. pylori, cagA and vacA, and multilocus sequence typing (MLST) are widely used markers for genomic diversity within H. pylori populations. There are two types of cagA: the East Asian type and the Western type. In addition, the right end of the cag pathogenicity island is divided into five subtypes and there are distinct mosaic structures at the signal region and the middle region of vacA. Using combinations of the cagA, cag right end junction, and vacA genotypes, five major groups (East Asia type, South/Central Asia type, Iberian/Africa type and Europe type) have been defined according to geographical associations. MLST has revealed seven modern population types and six ancestral population types of H. pylori, and is a useful tool for mapping human migration patterns. Serial studies of large numbers of H. pylori strains, including strains isolated from aboriginal populations, show that MLST analysis provides more detailed information on human migration than does the analysis of human genetics. H. pylori infection is rapidly declining as a result of improvements in personal hygiene and quality of life. The molecular epidemiology of H. pylori infection has much to tell us and should be studied before it disappears entirely.
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影响因子：
29.4
作者：
Naito, M;Yamazaki, T;Hatakeyama, M
通讯作者：
Hatakeyama, M
影响因子：
3.4
作者：
Backert, S;Ziska, E;Meyer, TF
通讯作者：
Meyer, TF
不同地理区域幽门螺杆菌的重组和克隆分组
影响因子：
3.6
作者：
Achtman, M;Azuma, T;van Doorn, LJ
通讯作者：
van Doorn, LJ
DOI：
10.1073/pnas.93.25.14648
发表时间：
1996-12-10
影响因子：
11.1
作者：
Censini, S;Lange, C;Covacci, A
通讯作者：
Covacci, A
DOI：
10.1093/jnci/87.23.1777
发表时间：
1995-12-06
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
KUIPERS, EJ;PEREZPEREZ, GI;BLASER, MJ
通讯作者：
BLASER, MJ