The LAT Story: A Tale of Cooperativity, Coordination, and Choreography
The LAT Story: A Tale of Cooperativity, Coordination, and Choreography
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DOI：
10.1101/cshperspect.a005512
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发表时间：
2010-08-01
影响因子：
7.2
通讯作者：
Sommers, Connie L.
中科院分区：
文献类型：
--
作者：
Balagopalan, Lakshmi;Coussens, Nathan P.;Sommers, Connie L.
接头分子 LAT 是多蛋白信号复合物的成核位点，对于 T 细胞的功能和分化至关重要。在多个实验系统中对 LAT 进行广泛研究，使人们对 LAT 有核信号复合物的形成、组成、调节、动态运动和功能有了全面的了解。这篇综述讨论了直接或间接与 LAT 结合的信号分子的相互作用，以及协同作用在稳定 LAT 有核信号复合物中的作用。此外，它还重点关注成像研究如何将信号组件可视化为信号簇，并展示其动态性质和细胞命运。最后，本综述基于使用各种 LAT 突变体的小鼠模型的解释，探讨了 LAT 的功能。
The adapter molecule LAT is a nucleating site for multiprotein signaling complexes that are vital for the function and differentiation of T cells. Extensive investigation of LAT in multiple experimental systems has led to an integrated understanding of the formation, composition, regulation, dynamic movement, and function of LAT-nucleated signaling complexes. This review discusses interactions of signaling molecules that bind directly or indirectly to LAT and the role of cooperativity in stabilizing LAT-nucleated signaling complexes. In addition, it focuses on how imaging studies visualize signaling assemblies as signaling clusters and demonstrate their dynamic nature and cellular fate. Finally, this review explores the function of LAT based on the interpretation of mouse models using various LAT mutants.