Serum 25-hydroxyvitamin D levels and psychological distress symptoms in patients with affective disorders during the COVID-19 pandemic
Serum 25-hydroxyvitamin D levels and psychological distress symptoms in patients with affective disorders during the COVID-19 pandemic
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DOI：
10.1016/j.psyneuen.2020.104869
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发表时间：
2020-12-01
影响因子：
3.7
通讯作者：
Sani, Gabriele
中科院分区：
文献类型：
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作者：
Di Nicola, Marco;Dattoli, Luigi;Sani, Gabriele
背景资料。新冠肺炎疫情在全球范围内引发了压力，特别是对精神疾病患者这样的弱势群体。本研究旨在调查一组重度抑郁障碍(MDD)或双相情感障碍(BD)患者在7周的封锁措施后感受到的心理痛苦，并分析血清25-羟基维生素D[25(OH)D]水平作为潜在预测痛苦严重程度的指标。59例缓解期MDD和53例心境正常的BD患者入选。使用凯斯勒10心理困难量表(K10)进行在线专项调查，获取新冠肺炎封锁相关信息，并对其进行评估。患者的医疗记录被审查以收集社会人口学和临床数据，包括在疫情爆发前三个月内服用的血清25(OH)D水平。采用多元一般线性模型检验兴趣因素对心理困扰的影响。在我们的样本(n=112)中，29名受试者(25.9%)报告没有心理困扰的可能性，而35名(31.2%)和48名(42.9%)分别有轻度和中度至重度心理困扰的可能性。低血25(OH)D水平(p=0.005)和MDD诊断(p=0.001)可特异性地预测心理困扰的严重程度。封锁期间独居、病程较长和吸烟习惯在患有新冠肺炎相关痛苦的受试者中更频繁地被检测到。低血清25(OH)D水平和MDD诊断预示着对新冠肺炎爆发的应激性影响的易感性增加。我们的结果表明，维生素D可能代表了一种生物学因素，调节了情感性障碍患者对压力的心理反应，并为量身定做干预策略提供了进一步的见解。
Background. The COVID-19 pandemic has given rise to stress worldwide, especially in vulnerable people like those suffering from mental illness. This study aims to investigate the psychological distress perceived by a cohort of patients with Major Depressive Disorder (MDD) or Bipolar Disorder (BD) after a seven-week period of lockdown measures, and to analyze serum 25-hydroxyvitamin D [25(OH)D] levels as a potential predictor of distress severity.Methods. Fifty-nine remitted MDD and fifty-three euthymic BD patients were enrolled. An online dedicated survey was administered to obtain lockdown-related information and to evaluate COVID-19 related distress by using the Kessler 10 Psychological Distress Scale (K10). Patients' medical records were reviewed to collect sociodemographic and clinical data, including serum 25(OH)D levels dosed in the three months preceding the outbreak. A multivariate general linear model was adopted to test the effect of factors of interest on psychological distress.Results. In our sample (n = 112), 29 subjects (25.9 %) reported no likelihood of psychological distress, whereas 35 (31.2 %) and 48 (42.9 %) displayed mild and moderate-to-severe likelihood of psychological distress, respectively. Low serum 25(OH)D levels (p = 0.005) and MDD diagnosis (p = 0.001) specifically predicted the severity of psychological distress. Living alone during the lockdown, a longer duration of illness, and smoking habits were more frequently detected in subjects with COVID-19 related distress.Conclusions. Low serum 25(OH)D levels and MDD diagnosis predicted an increased vulnerability to the stressful impact of the COVID-19 outbreak. Our results suggest that vitamin D may represent a biological factor mediating the psychological response to stress in individuals with affective disorders and provide further insight into tailoring intervention strategies.