Ascorbate-induced cancellation of nitroxide contrast media enhancement of MR images.
Ascorbate-induced cancellation of nitroxide contrast media enhancement of MR images.
复制标题
抗坏血酸诱导的硝基氧造影剂的抵消增强了 MR 图像。
DOI：
10.1097/00004424-198909000-00008
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发表时间：
1989
影响因子：
6.7
通讯作者：
Brasch,RC
中科院分区：
文献类型：
--
作者：
Wikstrom,MG;White,DL;Moseley,ME;Dupon,JW;Brasch,RC
抗坏血酸盐（维生素C），一种天然存在的还原物质，作为体内化学试剂进行了测试，以消除磁共振成像（MRI）组织对比度增强诱导的氮氧自旋标记造影剂。顺磁性氮氧化合物可以在体外被抗坏血酸还原成非顺磁性的羟胺衍生物。在11只麻醉大鼠中静脉注射氮氧自由基剂TES，2 mmol/kg。肾皮质和肝脏的强度监测系列T1加权图像（TR/TE 310/IS）获得的前增强和增强后。TES给药后14 min，6只大鼠注射抗坏血酸（1 mmol/kg），5只对照组大鼠注射生理盐水。造影后29分钟，对所有大鼠进行第二次TES注射。最初的TES注射导致肾皮质和肝脏的显著增强。抗坏血酸管理立即取消这种增强。通过重复使用TES可以成功地再次引起对比增强。结果表明，在体内给药的还原剂可以用来立即取消增强诱导的氮氧化物造影剂，因此，非增强图像可以得到增强后的图像，而没有长时间的延迟造影剂消除。
Ascorbate (Vitamin C), a naturally occurring reducing substance, was tested as an in vivo chemical agent to cancel magnetic resonance imaging (MRI) tissue contrast enhancement induced by a nitroxide spin label contrast agent. Paramagnetic nitroxide compounds can be reduced in vitro by ascorbate to nonparamagnetic hydroxylamine derivatives. A nitroxide agent, TES, was injected intravenously, 2 mmol/kg, in 11 anesthetized rats. Renal cortical and hepatic intensities were monitored by serial T1-weighted images (TR/TE 310/IS) acquired precontrast and postcontrast. Fourteen minutes after TES administration, ascorbate (1mmol/kg) was injected in 6 rats, and saline in 5 control rats. At twenty-nine minutes postcontrast, a second TES-injection was given to all rats. The initial TES-injection resulted in a marked enhancement of kidney cortex and liver. Ascorbate administration immediately cancelled this enhancement. Contrast enhancement could be successfully reinduced by a repeat administration of TES. Results indicate that in vivo administration of reducing agents can be used to immediately cancel enhancement induced by nitroxide contrast media, thus nonenhanced images could be obtained after enhanced images without lengthy delays for contrast media elimination.