A high degree of HLA disparity arises from limited allelic diversity: Analysis of 1775 unrelated bone marrow transplant donor-recipient pairs
A high degree of HLA disparity arises from limited allelic diversity: Analysis of 1775 unrelated bone marrow transplant donor-recipient pairs
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DOI：
10.1016/j.humimm.2006.09.004
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发表时间：
2007-01-01
期刊：
影响因子：
2.7
通讯作者：
Setterholm, Michelle
中科院分区：
文献类型：
--
作者：
Hurley, Carolyn Katovich;Fernandez-Vina, Marcelo;Setterholm, Michelle
回顾性分析了 1775 名骨髓受者及其无关捐献者的等位基因多样性和相关人类白细胞抗原 (HLA) 差异，匹配了 6 种 HLA-A、-B、-DR 抗原中的 6 种（1361/1775，77%）、6 种中的 5 种（397/1775，22%）或 6 种 HLA-A、-B、-DR 抗原中的 4 种（17/1775，1%）。 评价。全面的 HLA 分析包括 I 类（A、B、C）和 II 类（DRB1、DQA1、DQB1、DPA1、DPB1）位点。大多数 (> 66%) 以白种人为主的研究人群在每个 HLA 基因座上携带 5 到 7 个常见等位基因中的一到两个。尽管多样性有限，六个抗原匹配移植物中的六个中的 29176 个在 HLA-A、-B 和/或 -DRB1 处携带等位基因错配，并且 9276 个在测试的八个 HLA 位点之一携带至少一个等位基因错配。在 968 个 HLA-A、-B、-DRB1 等位基因匹配对中，89% 在其他 HLA 基因座（主要是 DP 基因座）上存在错配。供体和受体之间的 HLA 等位基因差异远大于预期，表明存在广泛的单倍型多样性，并强调了加强方法以减轻 HLA 错配的有害影响的重要性。
The allelic diversity and associated human leukocyte antigen (HLA) disparity of 1775 bone marrow recipients and their unrelated donors, matched for six of six (1361/1775, 77%), five of six (397/1775, 22%), or four of six (17/1775, 1%) HLA-A, -B, -DR antigens, were retrospectively evaluated. The comprehensive HLA analysis included the class I (A, B, C) and II (DRB1, DQA1, DQB1, DPA1, DPB1) loci. Most (> 66%) of the predominantly Caucasian study population carried one or two of five to seven common alleles at each HLA locus. In spite of this limited diversity, 29176 of the six of six antigen-matched transplants carried allele mismatches at HLA-A, -B, and/or -DRB1, and 9276 carried at least one allele mismatch at one of the eight HLA loci tested. Of the 968 HLA-A,-B,-DRB1 allele-matched pairs, 89% carried mismatches at other HLA loci, predominantly at DP loci. The substantially greater than expected HLA allelic disparity between donor and recipient suggests extensive haplotypic diversity and underscores the importance of enhancing approaches to mitigate the deleterious effect of HLA mismatches.