Role of metallothionein in detoxification and tolerance to transition metals.
Role of metallothionein in detoxification and tolerance to transition metals.
复制标题
金属硫蛋白在解毒和过渡金属耐受中的作用。
DOI：
10.1007/978-3-0348-6784-9_43
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Smith,B
中科院分区：
文献类型：
--
作者：
Huang,PC;Morris,S;Dinman,J;Pine,R;Smith,B
Animal tolerance to the transition metals cadmium and zinc is hereditary. The evolution to a high level of resistance can be accelerated through mutation and selective pressure. We have studied inbred strains of mice and mutants of Chinese hamster ovary cells resistant to cadmium to further these understandings. Results with whole animals show that the difference in the rate and level of metallothionein accumulation is at most twofold between sensitive and resistant strains. However, with cadmium resistant CHO mutant cells, there is an over 60 fold increase in metallothionein and its mRNA upon induction. These mutants show over 60 fold amplification in metallothionein genes. These results offer a direct contrast in the correlation between elevation of metal resistance and increases in metallothionein between two genetic systems.
