Postnatal Change in Sulcal Length Asymmetry in Cerebrum of Cynomolgus Monkeys (Macaca fascicularis)
Postnatal Change in Sulcal Length Asymmetry in Cerebrum of Cynomolgus Monkeys (Macaca fascicularis)
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食蟹猴（猕猴）大脑脑沟长度不对称性的出生后变化
DOI：
10.1002/ar.22847
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Fukui Y
中科院分区：
文献类型：
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作者：
Sakamoto K;Sawada K;Fukunishi K;Imai N;Sakata-Haga H;Fukui Y
本研究的目的是确定雄性食蟹猴大脑出生后发育过程中成年型脑沟长度不对称的发生时间。猴的大脑在3个月大的时候就已经达到了成年的大小，尽管此时的体重仅占成年体重的1/8。额枕长度和大脑宽度在出生后也达到了成人水平，没有左/右偏差。一致地，主要初级沟的长度在 3 个月大时达到成年水平，然后在性成熟的猴子（4-6.5 岁）中略有下降。不对称商分析表明，沟长度不对称模式在出生后发育过程中逐渐发生变化。成年雄性沟长度不对称的模式是在24月龄后获得的。特别是，通过三向方差分析揭示了大脑成熟过程中弓状沟长度的年龄依赖性右偏。结果表明，从青春期到成年早期大脑成熟的区域差异改变了雄性食蟹猴的脑沟形态，具有特征性的不对称模式。 Anat Rec，297:200–207，2014 年。© 2013 Wiley periodicals, Inc.
The purpose of this study was to determine the timing of the onset of adult‐type sulcal length asymmetry during postnatal development of the male cynomolgus monkey cerebrum. The monkey brain has already reached adult size by 3 months of age, although the body weight only represents 1/8 of the adult body weight by that time. The fronto‐occipital length and the cerebral width also reached adult levels by that postnatal age with no left/right bias. Consistently, lengths of the major primary sulci reached adult levels by 3 months of age, and then decreased slightly in sexually mature monkeys (4–6.5 years of age). Asymmetry quotient analysis showed that sulcal length asymmetry patterns gradually changed during postnatal development. The male adult pattern of sulcal length asymmetry was acquired after 24 months of age. In particular, age‐dependent rightward lateralization of the arcuate sulcal length was revealed during cerebral maturation by three‐way ANOVA. The results suggest that the regional difference in cerebral maturation from adolescence to young adulthood modifies the sulcal morphology with characteristic asymmetric patterns in male cynomolgus monkeys. Anat Rec, 297:200–207, 2014. © 2013 Wiley Periodicals, Inc.