Virgin soil: The spread of visceral leishmaniasis into Uttar Pradesh, India
Virgin soil: The spread of visceral leishmaniasis into Uttar Pradesh, India
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DOI：
10.4269/ajtmh.2005.73.720
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发表时间：
2005-10-01
影响因子：
3.3
通讯作者：
Sundar, S
中科院分区：
文献类型：
--
作者：
Barnett, PG;Singh, SP;Sundar, S
我们进行了一项横断面研究，以确定内脏利什曼病（VL）的发病率和危险因素在两个村庄在北方邦，印度报告有最近爆发。自2001年以来，在245户2，203人中，我们检测到3例当前VL病例，32例既往病例和8例VL死亡（年发病率= 6/1，000）。危险因素包括与VL病例生活在同一个家庭（一个村庄的比值比[OR] = 76，P < 0.0005，另一个村庄的比值比[OR]= 22，P < 0.0005），夏天睡在楼下和外面（OR = 4.7，P = 0.004），年龄≥ 15岁（OR = 2.9，P = 0.024）。在一个村庄，牛的密度增加是一个危险因素，而在另一个村庄则不是。我们无法确定VL进入那些村庄的路线。我们的数据表明VL在以前未受影响的地区出现了新的传播。我们建议在仔细监督下喷洒滴滴涕，进行监测以查明其他受影响的村庄，并努力增加诊断和治疗设施。
We conducted a cross-sectional study to determine the incidence of visceral leishmaniasis (VL) and risk factors in two villages in Uttar Pradesh, India reported to have had a recent outbreak. In 245 households with 2,203 people, we detected 3 current VL cases, 32 past cases, and 8 VL deaths since 2001 (annual incidence = 6 per 1,000). Risk factors included living in the same household as a VL case (odds ratio [OR] = 76, P < 0.0005 in one village and OR = 22, P < 0.0005 in the other village), sleeping downstairs and outside in the summer (OR = 4.7, P = 0.004), and an age >= 15 years old (OR = 2.9, P = 0.024). Increasing cattle density was a risk factor in one village but not the other. We were not able to determine the route by which VL entered the villages. Our data demonstrate a new spread of VL in previously unaffected areas. We recommend carefully supervised spraying with DDT, surveillance to pinpoint other affected villages, and efforts to increase availability of diagnostic and treatment facilities.