[Gene therapy of vascular diseases].
[Gene therapy of vascular diseases].
复制标题
血管疾病的基因治疗。
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
A. Zelenin
中科院分区：
文献类型：
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作者：
A. Zelenin
血管疾病的基因治疗代表了现代生物医学的一个新领域。它基于利用基因结构进行医疗。该论文回顾了血管疾病基因治疗的主要方向：抑制血管壁增殖过程；将负责一氧化氮合成的基因注入血管壁元件；血压调节系统正常化；血栓栓塞因子和抗凝剂的合成；动脉粥样硬化的基因治疗；缺血心肌的血运重建和肿瘤血管化的抑制。
Gene therapy of vascular diseases represents a new perspective field in the modern biomedical science. It is based on the employment of genetic constructions for medical treatment. The paper reviews major directions in gene therapy of vascular diseases: inhibition of proliferative processes in the vascular wall; administration into the elements of vascular wall of genes responsible for nitric oxide synthesis; normalisation of blood pressure regulatory system; synthesis of thromboembolic factors and anticoagulants; gene therapy of atherosclerosis; revascularisation of ischaemic myocardium and inhibition of tumor vascularisation.