PENICILLIUM-MARNEFFEI INFECTION - AN UNDERDIAGNOSED DISEASE
PENICILLIUM-MARNEFFEI INFECTION - AN UNDERDIAGNOSED DISEASE
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DOI：
10.1111/j.1365-2559.1988.tb02041.x
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发表时间：
1988-09-01
期刊：
影响因子：
6.4
通讯作者：
CHAN, NK
中科院分区：
文献类型：
--
作者：
TSANG, DNC;CHAN, JKC;CHAN, NK
马尔尼菲青霉菌是一种罕见的人类病原体，在临床和组织学诊断中经常引起问题。报告1例自身免疫性溶血性贫血和肝脾肿大，随后被发现患有播散性马尔尼菲青霉菌感染。肝活检仅显示上皮样细胞肉芽肿，最初被认为是最有可能的诊断。正确的诊断在随后的结肠活检中变得明显，活检显示含有青霉菌的巨噬细胞广泛渗透。
Penicillium marneffei is a rare human pathogen that often causes problems in clinical and histological diagnosis. A patient who presented with autoimmune haemolytic anaemia and hepatosplenomegaly, and was subsequently found to be suffering from disseminated Penicillium marneffei infection, is reported. The liver biopsy showed epithelioid cell granulomas only, and tuberculosis was initially considered the most likely diagnosis. The correct diagnosis became evident in a subsequent colonic biopsy, which showed extensive infiltration by penicillium-laden macrophages.