MiR-145, miR-133a and miR-133b inhibit proliferation, migration, invasion and cell cycle progression via targeting transcription factor Sp1 in gastric cancer
MiR-145, miR-133a and miR-133b inhibit proliferation, migration, invasion and cell cycle progression via targeting transcription factor Sp1 in gastric cancer
复制标题
miR-145、miR-133a 和 miR-133b 通过靶向转录因子 Sp1 抑制胃癌的增殖、迁移、侵袭和细胞周期进展
DOI：
10.1016/j.febslet.2014.02.054
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发表时间：
2014-04-02
期刊：
影响因子：
3.5
通讯作者：
Liu, Ping
中科院分区：
文献类型：
--
作者：
Qiu, Tianzhu;Zhou, Xin;Liu, Ping
MicroRNA 最近已成为胃癌的关键调节因子。在这里，我们发现miR-145、miR-133a和miR-133b在胃癌组织和细胞系中下调。 miR-145、miR-133a 和 miR-133b 的过表达可诱导 G1 细胞周期停滞，并在体外抑制细胞增殖、迁移和侵袭。 miR-145、miR-133a 和 miR-133b 靶向转录因子 SP1，敲低 SP1 会降低参与细胞生长和侵袭的 MMP-9 和 Cyclin D1 的表达。因此，我们的研究结果首次证明miR-145、miR-133a和miR-133b通过降低Sp1及其下游蛋白的表达来抑制胃癌细胞的增殖、迁移、侵袭和细胞周期进展。 (C) 2014 年欧洲生化学会联合会。由 Elsevier B.V 出版。保留所有权利。
MicroRNAs have recently emerged as key regulators of gastric cancers. Here we found that miR-145, miR-133a and miR-133b were down-regulated in gastric cancer tissues and cell lines. Overexpression of miR-145, miR-133a and miR-133b induced G1 cell cycle arrest and inhibited cell proliferation, migration and invasion in vitro. MiR-145, miR-133a and miR-133b targeted the transcription factor SP1, knockdown of which reduced the expression of MMP-9 and Cyclin D1 that were involved in cell growth and invasion. Thus, our findings demonstrated for the first time that miR-145, miR-133a and miR-133b suppressed the proliferation, migration, invasion and cell cycle progression of gastric cancer cells through decreasing expression of Sp1 and its downstream proteins. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.