HUMAN APOLIPOPROTEIN-B - STRUCTURE OF CARBOXYL-TERMINAL DOMAINS, SITES OF GENE-EXPRESSION, AND CHROMOSOMAL LOCALIZATION
HUMAN APOLIPOPROTEIN-B - STRUCTURE OF CARBOXYL-TERMINAL DOMAINS, SITES OF GENE-EXPRESSION, AND CHROMOSOMAL LOCALIZATION
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DOI：
10.1126/science.2994225
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
SCOTT, J
中科院分区：
文献类型：
--
作者：
KNOTT, TJ;RALL, SC;SCOTT, J
载脂蛋白（apo-）B是负责受体介导的低密度脂蛋白（血浆中主要的胆固醇转运脂蛋白）催化的配体。从人apo-B（apo-B 100）的互补DNA的核苷酸序列推导出了其羧基端30%（1455个氨基酸）的一级结构。已经鉴定了可能与其受体结合功能和脂质结合特性相关的蛋白质结构部分。apo-B100信使RNA的长度约为19个碱基。apo-B100基因主要在肝脏中表达，在较小程度上在小肠中表达，但在其他组织中不表达。apo-B100的基因位于2号染色体的p24区域（靠近短臂的尖端）。
Apolipoprotein (apo-) B is the ligand responsible for the receptor-mediated catabolism of low density lipoproteins, the principal cholesterol-transporting lipoproteins in plasma. The primary structure of the carboxyl-terminal 30 percent (1455 amino acids) of human apo-B (apo-B100) has been deduced from the nucleotide sequence of complementary DNA. Portions of the protein structure that may relate to its receptor binding function and lipid binding properties have been identified. The apo-B100 messenger RNA is about 19 kilobases in length. The apo-B100 gene is expressed primarily in liver and, to a lesser extent, in small intestine, but in no other tissues. The gene for apo-B100 is located in the p24 region (near the tip of the short arm) of chromosome 2.