Chromosomal alterations in lung metastases of colorectal carcinomas:: Associations with tissue specific tumor dissemination
Chromosomal alterations in lung metastases of colorectal carcinomas:: Associations with tissue specific tumor dissemination
复制标题
DOI：
10.1007/s10585-005-5239-7
复制
发表时间：
2005-11-01
影响因子：
4
通讯作者：
Petersen, I
中科院分区：
文献类型：
--
作者：
Knösel, T;Schlüns, K;Petersen, I
比较基因组杂交用于筛选与肺转移表型相关的结直肠癌染色体畸变。研究了13个肺转移瘤、6个原发性肿瘤、1个淋巴结转移瘤、1个肝转移瘤和1个卵巢转移瘤的样本，并将其添加到我们的CGH结肠癌肿瘤集合中，包括来自56名患者的85个肿瘤样本（参见CGH在线肿瘤数据库http：//amba.charite.de/cgh）。肺转移瘤比肝转移瘤表现出更多的改变，特别是1p、3p、9q、12q、17q、19p和22q的缺失更多，2q、5p和6号染色体的增加更多。肺转移瘤与其相应的原发肿瘤相比，特别是观察到更多的3p，8p，12q，17q和21q21缺失和5p增益。根据我们的结果，我们希望提出一个转移进展模型。转移性细胞的特定亚群具有独特的转移潜力，这通过染色体改变的非随机积累来反映。在原发性肿瘤中已经存在明显的改变，这种“准备就绪的包装”使细胞具有转移潜力，以实现转移所需的一系列复杂事件。
Comparative genomic hybridization was used to screen colorectal carcinomas for chromosomal aberrations that are associated with the metastatic phenotype of the lung. Specimens of 13 lung metastases, 6 primary tumors, 1 lymph node metastasis, 1 liver metastasis, and 1 ovarian metastasis were investigated and added to our CGH colon cancer tumor collective, comprising 85 tumor specimens from 56 patients (see CGH online tumor database at http://amba.charite.de/cgh). Lung metastases showed more alterations than liver metastases, particularly more deletions at 1p, 3p, 9q, 12q, 17q, 19p and 22q and gains at 2q, 5p, and chromosome 6. Comparing lung metastases with their corresponding primary tumors, particularly more deletions at 3p, 8p, 12q, 17q, and 21q21 and gains at 5p were observed. Based on our results, we wish to suggest a metastatic progression model. Specific subpopulations of metastatic cells have a distinct metastatic potential, which is reflected by a non-random accumulation of chromosomal alterations. Distinct alterations already exist within the primary tumor and this "ready to go package" gives the cells the metastatic potential to achieve the complex series of events needed for metastasis.