Metrics to 'green' chemistry - which are the best?
Metrics to 'green' chemistry - which are the best?
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DOI：
10.1039/b206169b
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发表时间：
2002-01-01
期刊：
影响因子：
9.8
通讯作者：
Cunningham, VL
中科院分区：
文献类型：
--
作者：
Constable, DJC;Curzons, AD;Cunningham, VL
关于使用衡量标准推动企业、政府和社区走向更可持续的做法，已经写了相当多的文章。在过去的5-10年里，还提出了一些度量标准，以使化学家意识到改变用于化学合成和化学过程的方法的必要性。本文探讨了化学家常用的几个指标，并将这些指标与一种名为反应质量效率的新指标进行了比较和对比。本文还对四个商业制药过程进行了经济分析，以了解这些过程中的指标和最重要的成本驱动因素之间的关系。
A considerable amount has been written about the use of metrics to drive business, government and communities towards more sustainable practices. A number of metrics have also been proposed over the past 5-10 years to make chemists aware of the need to change the methods used for chemical syntheses and chemical processes. This paper explores several metrics commonly used by chemists and compares and contrasts these metrics with a new metric known as reaction mass efficiency. The paper also uses an economic analysis of four commercial pharmaceutical processes to understand the relationship between metrics and the most important cost drivers in these processes.