Adult T-cell leukemia-lymphoma in a pregnant woman diagnosed as a human T-cell lymphotropic virus type 1 carrier
Adult T-cell leukemia-lymphoma in a pregnant woman diagnosed as a human T-cell lymphotropic virus type 1 carrier
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DOI：
10.1111/jog.12904
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发表时间：
2016-03-01
影响因子：
1.6
通讯作者：
Masuzaki, Hideaki
中科院分区：
文献类型：
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作者：
Fuchi, Naoki;Miura, Kiyonori;Masuzaki, Hideaki
人类T细胞白血病病毒1型（HTLV-1）是成人T细胞白血病-淋巴瘤（ATL）的病原体，是一种难以治愈的疾病。在日本，自2011年以来一直建议在全国范围内对孕妇进行HTLV-1筛查。一名30岁的妇女在前一次怀孕时被诊断为HTLV-1携带者。在当前妊娠期间，她持续发热和咳嗽。虽然她接受了抗生素治疗，但外周白色血细胞计数仍然很高，淋巴细胞计数异常。鉴于她是HTLV-1携带者，她在妊娠12周时被诊断患有不利的慢性ATL（侵袭性ATL）。终止妊娠后，她的ATL状态变为有利的慢性ATL（惰性ATL）。因此，观察等待直至疾病进展。这是首例妊娠早期慢性ATL的病例报告，患者在筛查试验中已被诊断为HTLV-1携带者。
Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia-lymphoma (ATL), which is difficult to cure. In Japan, a nationwide HTLV-1 screening test in pregnant women has been recommended since 2011. A 30-year-old woman was diagnosed as being an HTLV-1 carrier in her previous pregnancy. During the current pregnancy, she had persistent fever and cough. Although she had treatment with antibiotics, peripheral white blood cell count remained high, with an abnormal lymphocyte count. Given that she was an HTLV-1 carrier, she was diagnosed with unfavorable chronic ATL (aggressive ATL) at 12 weeks gestation. After pregnancy termination, her ATL status became favorable chronic ATL (indolent ATL). Therefore, watchful waiting was performed until disease progression. This is the first case report of chronic ATL in early pregnancy, in a woman already diagnosed as an HTLV-1 carrier on screening test.