Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment
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DOI：
10.1007/s10147-005-0546-1
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发表时间：
2006-02
影响因子：
3.3
通讯作者：
T. Shiozawa;I. Konishi
中科院分区：
文献类型：
--
作者：
T. Shiozawa;I. Konishi
子宫内膜癌患者的数量在日本显著增加。因此，了解其生物学特性和建立适当的治疗方法是重要的。在本文中，我们首先描述了这两种类型的子宫内膜癌的临床病理与激素背景和遗传学改变，然后讨论早期子宫内膜癌的发生途径。此外，我们还审查了目前存在争议的早期子宫内膜癌的诊断和治疗方式，特别是术后治疗策略。
The number of patients with endometrial carcinoma is markedly increasing in Japan. Therefore, understanding of its biological characteristics and establishment of appropriate treatment are important. In this article, we first describe the clinicopathology of the two types of endometrial carcinoma with their hormonal background and genetic alterations, and then discuss the pathways of early endometrial carcinogenesis. In addition, we also review the diagnostic and therapeutic modalities for early endometrial carcinomas with current controversies, especially regarding postoperative treatment strategies.