Systematic interindividual differences in neurobehavioral impairment from sleep loss: evidence of trait-like differential vulnerability.
Systematic interindividual differences in neurobehavioral impairment from sleep loss: evidence of trait-like differential vulnerability.
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DOI：
10.1093/sleep/27.3.423
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发表时间：
2004-05
期刊：
影响因子：
5.6
通讯作者：
H. V. Van Dongen;M. Baynard;G. Maislin;D. Dinges
中科院分区：
文献类型：
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作者：
H. V. Van Dongen;M. Baynard;G. Maislin;D. Dinges
目的研究睡眠剥夺期间神经行为缺陷的个体间差异，并确定睡眠丧失的神经行为反应在多大程度上是睡眠史与特质样差异脆弱性的函数。设计：个体在3个不同的场合被暴露于睡眠剥夺，以确定神经行为损害的个体间差异的稳定性。实验地点：睡眠剥夺实验在标准化实验室条件下进行，并持续监测清醒状态。在进入睡眠剥夺阶段之前，每个受试者都经历了一次实验室适应期。受试者：21名健康成年人（年龄21-38岁）完成实验。干预受试者来到实验室3次，间隔至少2周。在每次实验室会议期间，他们在36小时的完全睡眠剥夺期间每2小时进行一次神经行为测试，之前是基线睡眠，之后是恢复睡眠。在每次睡眠剥夺前一周和实验室的基线夜晚，受试者被要求将他们的睡眠限制在每天6小时（之前的睡眠限制条件）或将他们在床上的时间延长到每天12小时（之前的睡眠延长条件），以便实验性地操纵睡眠历史（以随机平衡顺序）。结果有强有力的证据表明，睡眠剥夺期间神经行为缺陷的个体间差异是系统的和特质样的。个体间差异的大小相对于先前睡眠限制的影响大小是相当大的（与先前睡眠延长相比，平均每天减少4.1小时睡眠，持续7天）。总体而言，个体间差异不能用受试者的基线功能或各种其他潜在的预测因素来解释。个体间差异集中在3个不同的神经行为维度上：自我评价嗜睡、疲劳和情绪;认知处理能力;以及通过持续注意力表现测量的行为警觉性。结论：睡眠不足导致的神经行为缺陷在个体间差异显著，在个体内是稳定的。个体间对睡眠剥夺的神经行为反应的差异不仅仅是睡眠史变化的结果。相反，它们涉及到对睡眠不足的损伤的类似特质的差异脆弱性，神经生物学相关性尚未被发现。
OBJECTIVES To investigate interindividual differences in neurobehavioral deficits during sleep deprivation, and to establish to what extent the neurobehavioral responses to sleep loss are a function of sleep history versus trait-like differential vulnerability. DESIGN Individuals were exposed to sleep deprivation on 3 separate occasions in order to determine the stability of interindividual differences in neurobehavioral impairment. SETTING The sleep-deprivation experiments were conducted under standardized laboratory conditions with continuous monitoring of wakefulness. Each subject underwent a laboratory-adaptation session before entering the sleep-deprivation phase of the study. PARTICIPANTS A total of 21 healthy adults (aged 21-38 years) completed the experiment. INTERVENTIONS Subjects came to the laboratory 3 times at intervals of at least 2 weeks. During each laboratory session, they underwent neurobehavioral testing every 2 hours during 36 hours of total sleep deprivation, which was preceded by baseline sleep and followed by recovery sleep. In the week prior to each sleep-deprivation session and on the baseline night in the laboratory, subjects were required to either restrict their sleep to 6 hours per day (prior sleep restriction condition) or to extend their time in bed to 12 hours per day (prior sleep extension condition), so as to experimentally manipulate sleep history (in randomized counterbalanced order). RESULTS There was strong evidence that interindividual differences in neurobehavioral deficits during sleep deprivation were systematic and trait-like. The magnitude of interindividual variability was substantial relative to the magnitude of the effect of prior sleep restriction (which on average involved a reduction of 4.1 hours sleep per day, compared to prior sleep extension, for 7 days). Overall, interindividual differences were not explained by subjects' baseline functioning or a variety of other potential predictors. Interindividual variability clustered on 3 distinct neurobehavioral dimensions: self-evaluation of sleepiness, fatigue, and mood; cognitive processing capability; and behavioral alertness as measured by sustained attention performance. CONCLUSIONS Neurobehavioral deficits from sleep loss varied significantly among individuals and were stable within individuals. Interindividual differences in neurobehavioral responses to sleep deprivation were not merely a consequence of variations in sleep history. Rather, they involved trait-like differential vulnerability to impairment from sleep loss, for which neurobiologic correlates have yet to be discovered.