Acute effects of ozone on mortality from the "Air pollution and health:: A European approach" project
Acute effects of ozone on mortality from the "Air pollution and health:: A European approach" project
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DOI：
10.1164/rccm.200403-333oc
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发表时间：
2004-11-15
影响因子：
24.7
通讯作者：
Dörtbudak, Z
中科院分区：
文献类型：
--
作者：
Gryparis, A;Forsberg, B;Dörtbudak, Z
在“空气污染与健康：欧洲办法”项目中，调查了环境臭氧浓度对死亡率的影响。收集了自1990年以来至少3年的23个城市/地区的每日臭氧浓度、每日死亡人数、混杂因素和潜在影响调节剂的数据。通过城市特定模型获得每个城市的效应估计值，并使用第二阶段回归模型进行合并。在寒冷的半年里没有观察到明显的影响。对于温暖的季节，1小时臭氧浓度增加10 mug/ml与0.33%相关（95%置信区间[CI]，0.17-0.52）每日死亡总数增加0.45%在心血管死亡人数中，死亡率为1.13%（95%CI，0.22-0.69），在呼吸道死亡人数中，死亡率为1.13%（95%CI，0.62-1.48）。8小时臭氧的相应数字相似。与总死亡率的关联是独立的SO2和空气动力学直径小于10妈妈（PM10）的颗粒物，但有点混淆NO2和CO。个别城市估计是异质性的总（较高的标准化死亡率与较大的影响）和心血管死亡率（较大的影响，在南方城市观察）。臭氧对夏季总死亡率影响的剂量-反应曲线没有明显偏离线性。
In the Air Pollution and Health: A European Approach (APHEA2) project, the effects of ambient ozone concentrations on mortality were investigated. Data were collected on daily ozone concentrations, the daily number of deaths, confounders, and potential effect modifiers from 23 cities/areas for at least 3 years since 1990. Effect estimates were obtained for each city with city-specific models and were combined using second-stage regression models. No significant effects were observed during the cold half of the year. For the warm season, an increase in the 1-hour ozone concentration by 10 mug/ml was associated with a 0.33% (95% confidence interval [CI], 0.17-0.52) increase in the total daily number of deaths, 0.45% (95% CI, 0.22-0.69) in the number of cardiovascular deaths, and 1.13% (95% CI, 0.62-1.48) in the number of respiratory deaths. The corresponding figures for the 8-hour ozone were similar. The associations with total mortality were independent of SO2 and particulate matter with aerodynamic diameter less than 10 mum (PM10) but were somewhat confounded by NO2 and CO. Individual city estimates were heterogeneous for total (a higher standardized mortality rate was associated with larger effects) and cardiovascular mortality (larger effects were observed in southern cities). The dose-response curve of ozone effects on total mortality during the summer did not deviate significantly from linearity.