Retrieval of high-fidelity memory arises from distributed cortical networks.
Retrieval of high-fidelity memory arises from distributed cortical networks.
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DOI：
10.1016/j.neuroimage.2017.01.062
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发表时间：
2017-04-01
期刊：
影响因子：
5.7
通讯作者：
Gazzaley A
中科院分区：
文献类型：
--
作者：
Wais PE;Jahanikia S;Steiner D;Stark CEL;Gazzaley A
内侧颞叶（MTL）的功能是记忆事实和事件的必要条件。这很可能是外侧皮质区域关键地引导认知控制过程，以调整与记忆检索最相关的高保真细节。在这里，功能性和结构性MRI的结果一致表明，详细情景记忆的检索来自外侧皮质-颞叶网络，包括额下和角回区域。研究结果还表明，基于低保真度、广义信息的物品识别，而不是基于相关情景细节检索产生的记忆，与MTL和外侧皮质区域之间的功能连接无关。此外，与分布的mtl -皮质网络相关的白质通路微观结构特性的个体差异，与助记辨别任务的更好表现呈正相关。
Medial temporal lobe (MTL) function is well established as necessary for memory of facts and events. It is likely that lateral cortical regions critically guide cognitive control processes to tune in high-fidelity details that are most relevant for memory retrieval. Here, convergent results from functional and structural MRI show that retrieval of detailed episodic memory arises from lateral cortical—MTL networks, including regions of inferior frontal and angular gyrii. Results also suggest that recognition of items based on low-fidelity, generalized information, rather than memory arising from retrieval of relevant episodic details, is not associated with functional connectivity between MTL and lateral cortical regions. Additionally, individual differences in microstructural properties in white matter pathways, associated with distributed MTL-cortical networks, are positively correlated with better performance on a mnemonic discrimination task.