SPINE UPDATE - AGING AND DEGENERATION OF THE HUMAN INTERVERTEBRAL DISC
SPINE UPDATE - AGING AND DEGENERATION OF THE HUMAN INTERVERTEBRAL DISC
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DOI：
10.1097/00007632-199506000-00022
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发表时间：
1995-06-01
期刊：
影响因子：
3
通讯作者：
BUCKWALTER, JA
中科院分区：
文献类型：
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作者：
BUCKWALTER, JA
人类椎间盘经历与年龄相关的退行性变化，这些退行性变化导致中年人和老年人的一些最常见的损伤和残疾原因：脊柱僵硬、颈部疼痛和背部疼痛。椎间盘的年龄相关性变性的潜在原因包括营养下降、活细胞损失、细胞衰老、基质蛋白的翻译后修饰、降解的基质分子的积累和基质的疲劳破坏。这些机制中最重要的似乎是减少中央椎间盘的营养，这允许细胞废物和降解的基质分子的积累，损害细胞营养，并导致pH水平下降，进一步损害细胞功能并可能导致细胞死亡。虽然椎间盘的老化变化似乎是不可避免的，但确定加速这些变化的活动和药物可能有助于降低椎间盘退变的速度和严重程度;最近的工作表明，可以开发再生椎间盘组织的方法。
Human intervertebral discs undergo age-related degenerative changes that contribute to some of the most common causes of impairment and disability for middle aged and older persons: spine stiffness, neck pain, and back pain. Potential causes of the age-related degeneration of intervertebral discs include declining nutrition, loss of viable cells, cell senescence, post-translational modification of matrix proteins, accumulation of degraded matrix molecules, and fatigue failure of the matrix. The most important of these mechanisms appears to be decreasing nutrition of the central disc that allows accumulation of cell waste products and degraded matrix molecules, impairs cell nutrition, and causes a fall in pH levels that further compromises cell function and may cause cell death. Although aging changes of the disc appear to be inevitable, identification of activities and agents that accelerate these changes may help decrease the rate and severity of disc degeneration; and recent work suggests that methods can be developed that will regenerate disc tissue.