Psychomotor performance deficits and their relation to prior nights' sleep amona individuals with primary insomnia
Psychomotor performance deficits and their relation to prior nights' sleep amona individuals with primary insomnia
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DOI：
10.1093/sleep/31.5.599
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发表时间：
2008-05-01
期刊：
影响因子：
5.6
通讯作者：
Krystal, Andrew D.
中科院分区：
文献类型：
--
作者：
Edinger, Jack D.;Means, Melanie K.;Krystal, Andrew D.
目的：探讨原发性失眠症（PI）患者的精神运动（反应时）表现缺陷及其与主客观睡眠测量的关系。设计和环境：本研究在附属VA和学术医疗中心进行，采用匹配组，横断面研究设计。参与者：79名（43名女性）PI患者（m -年龄= 50.0 +/- 17.1岁）和84名（41名女性）筛选良好的正常睡眠者（年龄为48.6 +/- 16.8岁）。方法和措施：参与者进行了3晚的多导睡眠图（PSG），随后进行了4次多次睡眠潜伏期测试（MSLT）的日间测试。在每次MSLT小睡之前，他们对自己的困倦程度进行评分，并完成包括简单反应时间（SRT）、连续表现（CPT）和4次转换注意力（SAT）测试在内的性能测试。性能测量包括平均反应延迟和每个受试者的测试内反应延迟的标准偏差。结果：PI患者报告白天更嗜睡（P = 0.001），但在MSLT上比正常睡眠者更清醒（P = 0.02）。多变量分析显示，与对照组相比，PI组在许多子测试中有更长的反应延迟和更大的反应变异性。回归分析显示，PSG和基于日记的睡眠测量都有助于预测白天的表现指数，尽管睡眠开始后的客观清醒时间似乎是白天测量的最佳单一预测因子。结论：结果证实，PI患者在应对具有挑战性的反应时间任务时确实表现出相对的精神运动表现缺陷，这些缺陷似乎与客观和主观睡眠缺陷有关。研究结果支持PI患者的日常抱怨，并建议使用复杂的反应时间任务来评估他们。
Objective: To examine psychomotor (reaction time) performance deficits and their relation to subjective and objective sleep measures among individuals with primary insomnia (PI).Design and Setting: This study was conducted at affiliated VA and academic medical centers using a matched-groups, cross-sectional research design.Participants: Seventy-nine (43 women) individuals with PI (M-Age = 50.0 +/- 17.1 y) and 84 (41 women) well-screened normal sleepers (MAge 48.6 +/- 16.8 y).Methods and Measures: Participants underwent 3 nights of polysomnography (PSG) followed by daytime testing with a 4-trial multiple sleep latency test (MSLT). Before each MSLT nap, they rated their sleepiness and completed a performance battery that included simple reaction time (SRT), continuous performance (CPT), and 4 switching attention (SAT) tests. Performance measures included the mean response latency and the standard deviation of each subject's within-test response latencies.Results: PI sufferers reported greater (P = 0.001) daytime sleepiness, but were significantly (P = 0.02), more alert than normal sleepers on the MSLT. Multivariate analyses showed the PI group had significantly longer response latencies and greater response variability across many of the subtests than did the controls. Regression analyses showed that both PSG- and diary-based sleep measures contributed to the prediction of daytime performance indices, although objective wake time after sleep onset appeared the best single predictor of the daytime measures.Conclusions: Results confirm that PI sufferers do show relative psychomotor performance deficits when responding to challenging reaction time tasks, and these deficits appear related to both objective and subjective sleep deficits. Findings support PI patients' diurnal complaints and suggest the usefulness of complex reaction time tasks for assessing them.