Effect of fibrinogenolytic products D and E on fibrinogen and albumin synthesis in the rat.
Effect of fibrinogenolytic products D and E on fibrinogen and albumin synthesis in the rat.
复制标题
纤维蛋白原分解产物D和E对大鼠纤维蛋白原和白蛋白合成的影响。
DOI：
10.1172/jci110069
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
S. Saunders
中科院分区：
文献类型：
--
作者：
J. Franks;R. Kirsch;L. Frith;L. Purves;W. Franks;J. Franks;P. Mason;S. Saunders
Previous studies are in conflict over the effect of infusing mixed fibrinogen-fibrin degradation products on fibrinogen synthesis, as determined by changes in fibrinogen concentration or by incorporation of labeled amino acids into fibrinogen. We have injected purified homologous fragments D1 and E into rats and measured their fibrinogen and albumin synthetic rates by the [14C]carbonate technique, a method that provides quantitative estimates of hepatic secretory protein synthesis. Fibrinogen fractional synthetic rates were increased 2.5 times in animals injected with fragment D1, compared with saline-injected controls. No increase were observed in fragment E-injected animals. Neither fragment produced changes in albumin synthesis. Fragment D increased plasma fibrinogen concentration, but did not raise plasma haptoglobin levels. These results suggest that fragment D is a regulator of fibrinogen synthesis.
