Self-assembled hydrogels utilizing polymer-nanoparticle interactions.
Self-assembled hydrogels utilizing polymer-nanoparticle interactions.
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DOI：
10.1038/ncomms7295
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发表时间：
2015-02-19
影响因子：
16.6
通讯作者：
Langer R
中科院分区：
文献类型：
--
作者：
Appel EA;Tibbitt MW;Webber MJ;Mattix BA;Veiseh O;Langer R
可模塑水凝胶在施加压力时流动并迅速自我愈合，由于它们提供了微创输送和适形应用，因此得到了越来越多的应用。在这里，我们报道了一种利用合理设计的聚合物-纳米颗粒相互作用来制备具有剪切变稀和自修复性能的自组装水凝胶的新范例。生物聚合物衍生物通过对纳米颗粒的选择性吸附而连接在一起。生物聚合物和纳米颗粒之间的瞬时和可逆相互作用使其能够在施加剪应力的情况下流动，然后在应力松弛时迅速自我愈合。我们开发了一种聚合物-纳米颗粒凝胶形成的物理描述，用于设计用于微创药物输送的生物兼容凝胶。由于凝胶的分级结构，亲水性和疏水性药物都可以在体外和体内以不同的释放曲线被包埋和释放。这项工作介绍了一种简单和可推广的可模塑水凝胶，适用于一系列生物医学和工业应用。
Mouldable hydrogels that flow upon applied stress and rapidly self-heal are increasingly utilised as they afford minimally invasive delivery and conformal application. Here we report a new paradigm for the fabrication of self-assembled hydrogels with shear-thinning and self-healing properties employing rationally engineered polymer-nanoparticle interactions. Biopolymer derivatives are linked together by selective adsorption to nanoparticles. The transient and reversible interactions between biopolymers and nanoparticles enable flow under applied shear stress, followed by rapid self-healing when the stress is relaxed. We develop a physical description of polymer-nanoparticle gel formation that is utilised to design biocompatible gels for minimally-invasive drug delivery. Owing to the hierarchical structure of the gel, both hydrophilic and hydrophobic drugs can be entrapped and delivered with differential release profiles, both in vitro and in vivo. The work introduces a facile and generalizable class of mouldable hydrogels amenable to a range of biomedical and industrial applications.