Obesity and the likelihood of sexual behavioral risk factors for HPV and cervical cancer.
Obesity and the likelihood of sexual behavioral risk factors for HPV and cervical cancer.
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肥胖以及 HPV 和宫颈癌性行为危险因素的可能性。
DOI：
10.1038/oby.2008.394
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
McCarthy,EllenP
中科院分区：
文献类型：
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作者：
Wee,ChristinaC;Huang,Annong;Huskey,KarenW;McCarthy,EllenP
肥胖与较高的宫颈癌死亡率有关，但其与性行为风险因素的关系尚不清楚，性行为风险因素使妇女易患人乳头瘤病毒（HPV）和宫颈癌。我们使用1999-2004年全国健康与营养调查中3329名年龄在20-59岁之间的女性参与者的数据，分析BMI与初次性交年龄、性伴侣数量、性活动中使用安全套、性传播疾病（STD）史、单纯疱疹病毒2 （HSV‐2）血清阳性和HPV患病率之间的关系。BMI与HPV患病率无关。轻度肥胖女性（体重指数30.0-34.9 kg/m2）报告有性传播疾病史的可能性最小（9%比正常体重的13%），前一年性伴侣≥2名的可能性最小（8%比13%），而超重女性（体重指数25.0-29.9 kg/m2）报告终身伴侣≥10名的可能性最小；在有多个性伴侣的人群中，BMI指数与过去一个月内不使用避孕套的性行为无关。在调整了年龄、种族/民族和受教育程度后，BMI较高的女性报告性行为风险因素的可能性低于正常体重的女性；然而，只有轻度肥胖女性报告有性传播疾病史（0.74,95%可信区间0.55-0.99）和去年有2个性伴侣（0.57,0.39-0.85）的比值比才有意义。调整后，较高的BMI与HSV - 2血清阳性无关。HPV和宫颈癌的性行为危险因素在肥胖女性中并不比正常体重女性更普遍，也不太可能解释肥胖女性中观察到的更高的宫颈癌死亡率。
Obesity is associated with higher cervical cancer mortality, but its relationship with sexual behavioral risk factors that predispose women to human papilloma virus (HPV) and cervical cancer is unclear. We used data from 3,329 women participants, aged 20–59 years, of the 1999–2004 National Health and Nutrition Examination Survey, to analyze the relationship between BMI and age at first intercourse, number of sexual partners, condom use during sexual activity, history of sexually transmitted disease (STD), herpes simplex virus 2 (HSV‐2) seropositivity, and HPV prevalence. BMI was not associated with the prevalence of HPV. Mildly obese women (BMI 30.0–34.9 kg/m2) were least likely to report a STD history (9% vs. 13% in normal weight) and ≥2 sexual partners in the previous year (8% vs. 13%) while overweight women (BMI 25.0–29.9 kg/m2) were least likely to report ≥10 lifetime partners; among those with multiple partners, BMI was not associated with sexual activity without condoms in the past month. After adjustment for age, race/ethnicity, and education, women with higher BMI were less likely to report sexual behavioral risk factors than normal‐weight women; however, odds ratios were only significant for mildly obese women for reporting a STD history (0.74, 95% confidence interval 0.55–0.99) and having ≥2 sexual partners in the last year (0.57, 0.39–0.85). Higher BMI was not associated with HSV‐2 seropositivity after adjustment. HPV and sexual behavioral risk factors for HPV and cervical cancer are not more prevalent in obese than normal‐weight women and unlikely to account for higher‐observed cervical cancer mortality in obese women.