Trail activity in human ovarian cancer cells: potentiation of the action of cytotoxic drugs.
Trail activity in human ovarian cancer cells: potentiation of the action of cytotoxic drugs.
复制标题
人卵巢癌细胞的追踪活性：细胞毒性药物作用的增强。
DOI：
10.1016/s0959-8049(01)00345-8
复制
发表时间：
2002
影响因子：
8.4
通讯作者：
Maurizio D'Incalci
中科院分区：
文献类型：
--
作者：
S. Vignati;A. Codegoni;Federica Polato;Massimo Broggini;Maurizio D'Incalci
The ability of the TRAIL ligand to induce cell killing in three ovarian cancer cell lines was investigated using a glutathione-S-transferase (GST)-TRAIL fusion protein. One of the three lines was sensitive to TRAIL, which induced cell killing in a range of concentrations similar to those necessary to kill the TRAIL-sensitive leukaemic cell line Jurkat. The relative mRNA expression of the four TRAIL receptors did not explain the different sensitivities of the three ovarian cancer cell lines to TRAIL treatment. The TRAIL-sensitive IGROV-1 cell line expressed slightly lower levels of the anti-apoptotic protein FLIP than the two TRAIL-insensitive cell lines (A2780 and SKOV-3). Nevertheless, although TRAIL did not significantly reduce cell growth in the A2780 and SKOV-3 cells it did enhance the activity of paclitaxel and cisplatin (DDP), the two most widely used drugs for the treatment of ovarian cancer, increasing their ability to induce apoptosis. The use of TRAIL in combination with classical anticancer agents might thus boost the apoptotic response, improving the activity of DDP and paclitaxel in ovarian cancer.
影响因子：
11.2
作者：
S. Kagawa;Chao He;J. Gu;P. Koch;S. Rha;J. Roth;S. Curley;L. Stephens;B. Fang
通讯作者：
S. Kagawa;Chao He;J. Gu;P. Koch;S. Rha;J. Roth;S. Curley;L. Stephens;B. Fang
影响因子：
10.5
作者：
Chen, XB;Ko, LJ;Prives, C
通讯作者：
Prives, C