Fasting serum gastrin and basal gastric acid secretion.
Fasting serum gastrin and basal gastric acid secretion.
复制标题
空腹血清胃泌素和基础胃酸分泌。
DOI：
10.1080/00365521.1975.12097037
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发表时间：
1975
影响因子：
1.9
通讯作者：
J. Myren
中科院分区：
文献类型：
--
作者：
H. Petersen;E. Schrumpf;J. Myren
在有（n = 51）和无（n = 40）消化性溃疡病的受试者中，检查了基础（BAO）30分钟的胃酸分泌，并对逐步增加剂量的五肽胃泌素进行了反应。无一例出现基础性胃酸缺乏。在插入胃管之前，取血用于血清胃泌素浓度（SG）的放射免疫测定。无溃疡组SG与BAO呈显著正相关。这主要是由于20名健康年轻志愿者的密切相关性。当BAO和SG分别表示为计算的最大酸反应（Vmax）和五肽胃泌素的半最大剂量（Km）的比例时，SG和BAO之间的正相关性得到改善，并且在消化性溃疡患者中也达到显著性。提示血清胃泌素浓度对基础胃分泌有一定的影响。
The gastric secretion of acid was examined 30 minutes basally (BAO) and in response to stepwise increasing doses of pentagastrin in subjects with (n = 51) and without (n = 40) peptic ulcer disease. None of them showed basal anacidity. Before insertion of the gastric tube, blood was taken for radioimmunological determination of the serum gastrin concentration (SG). A significant positive correlation was found between SG and BAO in the subjects without ulcer. This was mainly due to a close correlation in 20 healthy young volunteers. When BAO and SG was expressed as proportions of calculated maximal acid response (Vmax) and half maximal dose of pentagastrin (Km), respectively, the positive correlation between SG and BAO was improved and reached significance also in the individuals with peptic ulcer disease. The findings suggest that the serum concentration of gastrin plays a role in the basal gastric secretion.