Human brain-derived acidic and basic fibroblast growth factors: amino terminal sequences and specific mitogenic activities.
Human brain-derived acidic and basic fibroblast growth factors: amino terminal sequences and specific mitogenic activities.
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人脑来源的酸性和碱性成纤维细胞生长因子：氨基末端序列和特定的有丝分裂活性。
DOI：
10.1016/0006-291x(86)90028-8
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发表时间：
1986
影响因子：
3.1
通讯作者：
Thomas,KA
中科院分区：
文献类型：
--
作者：
Gimenez-Gallego,G;Conn,G;Hatcher,VB;Thomas,KA
对来自人脑的酸性和碱性成纤维细胞生长因子进行的延伸氨基末端序列测定表明，它们彼此以及与各自的牛成纤维细胞生长因子具有广泛的同源性。两种人生长因子在肝素存在下对培养的人脐静脉内皮细胞具有相同的特异性促有丝分裂活性，而在没有肝素的情况下，酸性有丝分裂原的活性不到碱性生长因子的1%。
Extended amino terminal sequence determinations, made on both acidic and basic fibroblast growth factors from human brain, showed extensive homology with each other and with their respective bovine counterparts. Both human growth factors in the presence of heparin have equivalent specific mitogenic activities on human umbilical vein endothelial cells in culture whereas in the absence of heparin, the acidic mitogen is less than 1% as active as the basic growth factor.