Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model.
Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model.
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DOI：
10.1016/j.ccr.2009.08.015
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发表时间：
2009-10-06
期刊：
影响因子：
50.3
通讯作者：
Lowe SW
中科院分区：
文献类型：
--
作者：
Bric A;Miething C;Bialucha CU;Scuoppo C;Zender L;Krasnitz A;Xuan Z;Zuber J;Wigler M;Hicks J;McCombie RW;Hemann MT;Hannon GJ;Powers S;Lowe SW
Short hairpin RNAs (shRNAs) capable of stably suppressing gene function by RNA interference (RNAi) can mimic tumor suppressor gene loss in mice. By selecting for shRNAs capable of accelerating lymphomagenesis in a well-characterized mouse lymphoma model, we identified over ten candidate tumor suppressors, including Sfrp1, Numb, Mek1, and Angiopoietin 2. Several components of the DNA damage response machinery were also identified, including Rad17, which acts as a haploinsufficient tumor suppressor that responds to oncogenic stress and whose loss is associated with poor prognosis in human patients. Our results emphasize the utility of in vivo RNAi screens, identify and validate a diverse set of tumor suppressors, and have therapeutic implications.
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影响因子：
64.8
作者：
Dominguez-Sola, David;Ying, Carol Y.;Dalla-Favera, Riccardo
通讯作者：
Dalla-Favera, Riccardo
影响因子：
30.8
作者：
Jhappan, C;Morse, HC;Merlino, G
通讯作者：
Merlino, G
影响因子：
4.8
作者：
Parker, AE;Van de Weyer, I;Luyten, WHML
通讯作者：
Luyten, WHML
影响因子：
64.8
作者：
Bao, SD;Tibbetts, RS;Wang, XF
通讯作者：
Wang, XF
影响因子：
50.3
作者：
Murphy DJ;Junttila MR;Pouyet L;Karnezis A;Shchors K;Bui DA;Brown-Swigart L;Johnson L;Evan GI
通讯作者：
Evan GI