OBSERVATIONS ON REMYELINATION IN RABBIT SPINAL-CORD FOLLOWING DEMYELINATION INDUCED BY LYSOLECITHIN
OBSERVATIONS ON REMYELINATION IN RABBIT SPINAL-CORD FOLLOWING DEMYELINATION INDUCED BY LYSOLECITHIN
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DOI：
10.1111/j.1365-2990.1978.tb00528.x
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发表时间：
1978-01-01
影响因子：
5
通讯作者：
BLAKEMORE, WF
中科院分区：
文献类型：
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作者：
BLAKEMORE, WF
[通过 EM] 在 24 只兔子中检查了椎管内注射少量溶血卵磷脂引起的脱髓鞘后发生的髓鞘再生的程度和类型。与大鼠和猫不同，接受此手术后，髓鞘再生即使在 6 个月后也未完成。存活，并且很少发生雪旺细胞侵袭。髓鞘再生和持续脱髓鞘轴突周围的细胞环境不同。髓鞘再生与星形胶质细胞的良好存在和髓鞘碎片的去除有关。持续脱髓鞘的轴突被髓鞘碎片和不良星形胶质细胞包围。显然，脱髓鞘轴突周围的环境影响少突胶质细胞髓鞘再生。
The extent and type of remyelination that occurred following demyelination induced by intraspinal injection of small volumes of lysolecithin were examined [by EM] in 24 rabbits. Unlike the rat and cat following this procedure remyelination was not complete even after 6 mo. survival, and little Schwann cell invasion occurred. The cellular environment around remyelinated and persistently demyelinated axons differed. Remyelination was associated with a good astrocytic presence and removal of myelin debris; persistently demyelinated axons were surrounded by myelin debris and a poor astrocytic presence. Apparently the environment around the demyelinated axon influences oligodendrocyte remyelination.